{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jellen LC"],"funding":["Michael J. Fox Foundation for Parkinson's Research","Michael J. Fox Foundation for Parkinson's Research"],"pagination":["116"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12056004"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["We previously demonstrated that kynurenine pathway (KP) dysregulation associates with Parkinson's disease (PD) and its symptoms. Here, we profiled 16 KP-related markers in a second, independent cohort; plasma: n = 202 (116 PD (\"OFF\"), 86 controls); CSF: n = 183 (108, 75). Consistent with previous findings, we detected significantly higher concentrations of neurotoxic 3-hydroxykynurenine in plasma and lower concentrations of neuroprotective kynurenic acid along with higher neurotoxic quinolinic acid/kynurenic acid ratios in CSF of PD patients. Additionally, 10 markers showed sex-based differences, with more pronounced dysregulation in females. These 10 markers loaded to a single principal component linked to higher UPDRS I and II scores. Together, this suggests a composite signature of KP d"],"journal":["NPJ Parkinson's disease"],"pubmed_title":["Sex differences in peripheral and central dysregulation of the kynurenine pathway in Parkinson's disease."],"pmcid":["PMC12056004"],"funding_grant_id":["MJFF-010296"],"pubmed_authors":["Kong L","Lewis MM","Madaj Z","Huang X","Brundin L","Johnson A","Isaguirre C","Sheldon RD","Escobar Galvis ML","Jellen LC","Sha Q"],"additional_accession":[]},"is_claimable":false,"name":"Sex differences in peripheral and central dysregulation of the kynurenine pathway in Parkinson's disease.","description":"We previously demonstrated that kynurenine pathway (KP) dysregulation associates with Parkinson's disease (PD) and its symptoms. Here, we profiled 16 KP-related markers in a second, independent cohort; plasma: n = 202 (116 PD (\"OFF\"), 86 controls); CSF: n = 183 (108, 75). Consistent with previous findings, we detected significantly higher concentrations of neurotoxic 3-hydroxykynurenine in plasma and lower concentrations of neuroprotective kynurenic acid along with higher neurotoxic quinolinic acid/kynurenic acid ratios in CSF of PD patients. Additionally, 10 markers showed sex-based differences, with more pronounced dysregulation in females. These 10 markers loaded to a single principal component linked to higher UPDRS I and II scores. Together, this suggests a composite signature of KP d","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-01T19:17:49.39Z","creation":"2026-05-21T03:09:04.75Z"},"accession":"S-EPMC12056004","cross_references":{"pubmed":["40328760"],"doi":["10.1038/s41531-025-00949-6"]}}