{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lei WY"],"funding":["Health Promotion Administration, Ministry of Health and Welfare, Taiwan"],"pagination":["2231-2240"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12056587"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["72(12)"],"pubmed_abstract":["<h4>Objective</h4>Screening and eradication of <i>Helicobacter pylori</i> help reduce disparities in the incidence of gastric cancer. We aimed to evaluate its acceptability and feasibility in the indigenous communities and develop a family index-case method to roll out this programme.<h4>Design</h4>We enrolled residents aged 20-60 years from Taiwanese indigenous communities to receive a course of test, treat, retest and re-treat initial treatment failures with the <sup>13</sup>C-urea breath tests and four-drug antibiotic treatments. We also invited the family members of a participant (constituting an index case) to join the programme and evaluated whether the infection rate would be higher in the positive index cases.<h4>Results</h4>Between 24 September 2018 and 31 December 2021, 15 057 pa"],"journal":["Gut"],"pubmed_title":["Eradicating &lt;i&gt;Helicobacter pylori&lt;/i&gt; via &lt;sup&gt;13&lt;/sup&gt;C-urea breath screening to prevent gastric cancer in indigenous communities: a population-based study and development of a family index-case method."],"pmcid":["PMC12056587"],"funding_grant_id":["A1111008"],"pubmed_authors":["Wen SH","Lin YW","Chen HH","Tien HW","Hsu TH","Wu JY","Subeq YM","Lee YC","Chia SL","Sun KP","Wu DC","Hsieh PC","Chen CL","Hsu YH","Lin LJ","Bair MJ","Graham DY","Chiang TH","Lee JY","Chuang SL","Chen YR","Tien O'Donnell F","Chu CH","Wu MS","Chang HC","Lei WY","Wu CC"],"additional_accession":[]},"is_claimable":false,"name":"Eradicating &lt;i&gt;Helicobacter pylori&lt;/i&gt; via &lt;sup&gt;13&lt;/sup&gt;C-urea breath screening to prevent gastric cancer in indigenous communities: a population-based study and development of a family index-case method.","description":"<h4>Objective</h4>Screening and eradication of <i>Helicobacter pylori</i> help reduce disparities in the incidence of gastric cancer. We aimed to evaluate its acceptability and feasibility in the indigenous communities and develop a family index-case method to roll out this programme.<h4>Design</h4>We enrolled residents aged 20-60 years from Taiwanese indigenous communities to receive a course of test, treat, retest and re-treat initial treatment failures with the <sup>13</sup>C-urea breath tests and four-drug antibiotic treatments. We also invited the family members of a participant (constituting an index case) to join the programme and evaluated whether the infection rate would be higher in the positive index cases.<h4>Results</h4>Between 24 September 2018 and 31 December 2021, 15 057 pa","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-06-01T18:04:18.554Z","creation":"2026-05-19T03:07:06.436Z"},"accession":"S-EPMC12056587","cross_references":{"pubmed":["37197905"],"doi":["10.1136/gutjnl-2023-329871"]}}