biostudies-literatureLei WYHealth Promotion Administration, Ministry of Health and Welfare, Taiwan2231-2240https://www.ebi.ac.uk/biostudies/studies/S-EPMC12056587biostudies-literatureUnknown72(12)<h4>Objective</h4>Screening and eradication of <i>Helicobacter pylori</i> help reduce disparities in the incidence of gastric cancer. We aimed to evaluate its acceptability and feasibility in the indigenous communities and develop a family index-case method to roll out this programme.<h4>Design</h4>We enrolled residents aged 20-60 years from Taiwanese indigenous communities to receive a course of test, treat, retest and re-treat initial treatment failures with the ¹³C-urea breath tests and four-drug antibiotic treatments. We also invited the family members of a participant (constituting an index case) to join the programme and evaluated whether the infection rate would be higher in the positive index cases.<h4>Results</h4>Between 24 September 2018 and 31 December 2021, 15 057 paGutEradicating &lt;i&gt;Helicobacter pylori&lt;/i&gt; via &lt;sup&gt;13&lt;/sup&gt;C-urea breath screening to prevent gastric cancer in indigenous communities: a population-based study and development of a family index-case method.PMC12056587A1111008Wen SHLin YWChen HHTien HWHsu THWu JYSubeq YMLee YCChia SLSun KPWu DCHsieh PCChen CLHsu YHLin LJBair MJGraham DYChiang THLee JYChuang SLChen YRTien O'Donnell FChu CHWu MSChang HCLei WYWu CCfalseEradicating &lt;i&gt;Helicobacter pylori&lt;/i&gt; via &lt;sup&gt;13&lt;/sup&gt;C-urea breath screening to prevent gastric cancer in indigenous communities: a population-based study and development of a family index-case method.<h4>Objective</h4>Screening and eradication of <i>Helicobacter pylori</i> help reduce disparities in the incidence of gastric cancer. We aimed to evaluate its acceptability and feasibility in the indigenous communities and develop a family index-case method to roll out this programme.<h4>Design</h4>We enrolled residents aged 20-60 years from Taiwanese indigenous communities to receive a course of test, treat, retest and re-treat initial treatment failures with the ¹³C-urea breath tests and four-drug antibiotic treatments. We also invited the family members of a participant (constituting an index case) to join the programme and evaluated whether the infection rate would be higher in the positive index cases.<h4>Results</h4>Between 24 September 2018 and 31 December 2021, 15 057 pa2023-01-01T00:00:00Z2023 Nov2026-06-01T18:04:18.554Z2026-05-19T03:07:06.436ZS-EPMC120565873719790510.1136/gutjnl-2023-329871