{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mehreen S"],"funding":["Quaid-i-Azam University"],"pagination":["14717-14729"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12056728"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(19)"],"pubmed_abstract":["Effective α-glucosidase inhibitors are vital for managing type 2 diabetes, emphasizing the need for novel and potent compounds. A series of novel <i>N</i>-phenoxyethylisatin hydrazones 1(a-l) have been synthesized and characterized by their spectral data, and in the case of 1l by its single crystal X-ray analysis. All the synthesized compounds were <i>in vitro</i> evaluated for their inhibition potential against the α-glucosidase enzyme. Interestingly, most of these compounds exhibited significant inhibitory activity against the α-glucosidase enzyme, with IC<sub>50</sub> values ranging from 3.64 ± 0.13 to 94.89 ± 0.64 μM compared to the standard drug, acarbose (IC<sub>50</sub> = 873.34 ± 1.67 μM). The compound 1e was found to be the most active compound of the series having an IC<sub>50</s"],"journal":["RSC advances"],"pubmed_title":["Synthesis, structural insights and bio-evaluation of &lt;i&gt;N&lt;/i&gt;-phenoxyethylisatin hydrazones as potent α-glucosidase inhibitors."],"pmcid":["PMC12056728"],"funding_grant_id":["13-419 RG/PHA/AS_CUNESCO FR: 3240279216"],"pubmed_authors":["Ullah A","Al-Harrasi A","Ali MI","Ullah S","Mehreen S","Anwar MU","Khan A","Hussain J","Zia M","Naseer MM","Muntha ST"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis, structural insights and bio-evaluation of &lt;i&gt;N&lt;/i&gt;-phenoxyethylisatin hydrazones as potent α-glucosidase inhibitors.","description":"Effective α-glucosidase inhibitors are vital for managing type 2 diabetes, emphasizing the need for novel and potent compounds. A series of novel <i>N</i>-phenoxyethylisatin hydrazones 1(a-l) have been synthesized and characterized by their spectral data, and in the case of 1l by its single crystal X-ray analysis. All the synthesized compounds were <i>in vitro</i> evaluated for their inhibition potential against the α-glucosidase enzyme. Interestingly, most of these compounds exhibited significant inhibitory activity against the α-glucosidase enzyme, with IC<sub>50</sub> values ranging from 3.64 ± 0.13 to 94.89 ± 0.64 μM compared to the standard drug, acarbose (IC<sub>50</sub> = 873.34 ± 1.67 μM). The compound 1e was found to be the most active compound of the series having an IC<sub>50</s","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-01T05:55:56.822Z","creation":"2026-04-08T09:46:01.543Z"},"accession":"S-EPMC12056728","cross_references":{"pubmed":["40337235"],"doi":["10.1039/d5ra00770d"]}}