biostudies-literatureMehreen SQuaid-i-Azam University14717-14729https://www.ebi.ac.uk/biostudies/studies/S-EPMC12056728biostudies-literatureUnknown15(19)Effective α-glucosidase inhibitors are vital for managing type 2 diabetes, emphasizing the need for novel and potent compounds. A series of novel <i>N</i>-phenoxyethylisatin hydrazones 1(a-l) have been synthesized and characterized by their spectral data, and in the case of 1l by its single crystal X-ray analysis. All the synthesized compounds were <i>in vitro</i> evaluated for their inhibition potential against the α-glucosidase enzyme. Interestingly, most of these compounds exhibited significant inhibitory activity against the α-glucosidase enzyme, with IC<sub>50</sub> values ranging from 3.64 ± 0.13 to 94.89 ± 0.64 μM compared to the standard drug, acarbose (IC<sub>50</sub> = 873.34 ± 1.67 μM). The compound 1e was found to be the most active compound of the series having an IC<sub>50</sRSC advancesSynthesis, structural insights and bio-evaluation of <i>N</i>-phenoxyethylisatin hydrazones as potent α-glucosidase inhibitors.PMC1205672813-419 RG/PHA/AS_CUNESCO FR: 3240279216Ullah AAl-Harrasi AAli MIUllah SMehreen SAnwar MUKhan AHussain JZia MNaseer MMMuntha STfalseSynthesis, structural insights and bio-evaluation of <i>N</i>-phenoxyethylisatin hydrazones as potent α-glucosidase inhibitors.Effective α-glucosidase inhibitors are vital for managing type 2 diabetes, emphasizing the need for novel and potent compounds. A series of novel <i>N</i>-phenoxyethylisatin hydrazones 1(a-l) have been synthesized and characterized by their spectral data, and in the case of 1l by its single crystal X-ray analysis. All the synthesized compounds were <i>in vitro</i> evaluated for their inhibition potential against the α-glucosidase enzyme. Interestingly, most of these compounds exhibited significant inhibitory activity against the α-glucosidase enzyme, with IC<sub>50</sub> values ranging from 3.64 ± 0.13 to 94.89 ± 0.64 μM compared to the standard drug, acarbose (IC<sub>50</sub> = 873.34 ± 1.67 μM). The compound 1e was found to be the most active compound of the series having an IC<sub>50</s2025-01-01T00:00:00Z2025 May2026-06-01T05:55:56.822Z2026-04-08T09:46:01.543ZS-EPMC120567284033723510.1039/d5ra00770d