{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Piche LC"],"funding":["Natural Sciences and Engineering Research Council of Canada","MAPAQ","MAPAQ (Innov'Action)"],"pagination":["448"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12057083"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(1)"],"pubmed_abstract":["<h4>Background</h4>Antibiotic resistance is a major issue affecting all spheres of human activity, including agriculture. One significant example is the Avian Pathogenic Escherichia coli (APEC), a bacterium that infects poultry and leads to substantial economic losses in the farming industry. As antibiotics lose efficacity, bacteriophages (phages) -viruses that specifically target bacteria-are emerging as a promising alternative to antibiotics for treating and preventing bacterial infections. However, bacteria can develop resistance to phages through various mechanisms. Studying the coevolution between a phage and its host bacterium is important to gain insight into the phage's potential as a therapeutic agent. This study investigates the evolutionary responses of an APEC strain and a labo"],"journal":["BMC genomics"],"pubmed_title":["Evolutionary responses of Escherichia coli to phage pressure: insights into mucoidy and colanic acid overexpression."],"pmcid":["PMC12057083"],"funding_grant_id":["RGPIN-2022-03321","IA120638"],"pubmed_authors":["Letourneau-Montminy MP","Labrie SJ","Lague P","Piche LC","Saucier L","Vincent AT","Bories S","Dubar R","Liato V","Paquet VE","Charette SJ"],"additional_accession":[]},"is_claimable":false,"name":"Evolutionary responses of Escherichia coli to phage pressure: insights into mucoidy and colanic acid overexpression.","description":"<h4>Background</h4>Antibiotic resistance is a major issue affecting all spheres of human activity, including agriculture. One significant example is the Avian Pathogenic Escherichia coli (APEC), a bacterium that infects poultry and leads to substantial economic losses in the farming industry. As antibiotics lose efficacity, bacteriophages (phages) -viruses that specifically target bacteria-are emerging as a promising alternative to antibiotics for treating and preventing bacterial infections. However, bacteria can develop resistance to phages through various mechanisms. Studying the coevolution between a phage and its host bacterium is important to gain insight into the phage's potential as a therapeutic agent. This study investigates the evolutionary responses of an APEC strain and a labo","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-01T05:57:31.518Z","creation":"2026-04-08T09:45:20.823Z"},"accession":"S-EPMC12057083","cross_references":{"pubmed":["40329173"],"doi":["10.1186/s12864-025-11605-x"]}}