biostudies-literatureUnknown11(19)Zhao PNoble metal-based high-entropy alloys (NM-HEAs) are promising catalysts because of their diverse compositions and complex surface structures, although understanding their formation and achieving precise atomic control remain challenging. Our team introduces a cost-effective synthesis method combining spray drying and thermal decomposition-reduction to produce HEA three-dimensional nanoframeworks (HEA-3DNFs) from quinary to octonary compositions, including Pt-, Ir-, Ru-, and PtRu-based HEAs. Mild heating in H2 facilitates simultaneous reduction of multiple elements, forming single-phase solid solution alloys. The PtNiCoCuRuIr HEA-3DNF exhibits superior methanol oxidation reaction performance (2637 milliamperes per milligram Pt), 15 times higher than commercial Pt black. Noble metals (Pt, RuScience advanceseadq8537https://www.ebi.ac.uk/biostudies/studies/S-EPMC12057660biostudies-literaturePrecise synthesis of targeted noble metal-based high-entropy alloy nanomaterials.PMC12057660Zhang GZhou NPi HChen JHao XLei CWang JYi WKan DXu BZhao PQi YChen XZhang BCao QfalsePrecise synthesis of targeted noble metal-based high-entropy alloy nanomaterials.Noble metal-based high-entropy alloys (NM-HEAs) are promising catalysts because of their diverse compositions and complex surface structures, although understanding their formation and achieving precise atomic control remain challenging. Our team introduces a cost-effective synthesis method combining spray drying and thermal decomposition-reduction to produce HEA three-dimensional nanoframeworks (HEA-3DNFs) from quinary to octonary compositions, including Pt-, Ir-, Ru-, and PtRu-based HEAs. Mild heating in H2 facilitates simultaneous reduction of multiple elements, forming single-phase solid solution alloys. The PtNiCoCuRuIr HEA-3DNF exhibits superior methanol oxidation reaction performance (2637 milliamperes per milligram Pt), 15 times higher than commercial Pt black. Noble metals (Pt, Ru2025-01-01T00:00:00Z2025 May2026-06-01T18:04:51.439Z2026-05-19T03:07:11.105ZS-EPMC120576604033395710.1126/sciadv.adq8537