{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ramteke P"],"funding":["NIA NIH HHS","Michael Michelson Fund","U.S. Department of Health &amp; Human Services | NIH | National Institute on Aging","U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)","Aspects of this research was conducted while JC was an Irene Diamond Fund/AFAR Postdoctoral Transition Awardee in Aging"],"pagination":["50"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12059161"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Intervertebral disc degeneration is a major risk factor contributing to chronic low back and neck pain. While the etiological factors for disc degeneration vary, age is still one of the most important risk factors. Recent studies have shown the promising role of SIRT6 in mammalian aging and skeletal tissue health, however its role in the intervertebral disc health remains unexplored. We investigated the contribution of SIRT6 to disc health by studying the age-dependent spinal phenotype of mice with conditional deletion of Sirt6 in the disc (Acan<sup>CreERT2</sup>; Sirt6<sup>fl/fl</sup>). Histological studies showed a degenerative phenotype in knockout mice compared to Sirt6<sup>fl/fl</sup> control mice at 12 months, which became pronounced at 24 months. RNA-Seq analysis of NP and AF tissue"],"journal":["Bone research"],"pubmed_title":["Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice."],"pmcid":["PMC12059161"],"funding_grant_id":["R01 AG078609","R01AG078609","R01AG073349","R01 AG073349","R01 AG044034","R01AG044034"],"pubmed_authors":["Ramteke P","Collins JA","Barve RA","Watson B","Risbud MV","Tsingas M","Johnston S","Tran VA","Mitra R","Toci M","Loeser RF"],"additional_accession":[]},"is_claimable":false,"name":"Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice.","description":"Intervertebral disc degeneration is a major risk factor contributing to chronic low back and neck pain. While the etiological factors for disc degeneration vary, age is still one of the most important risk factors. Recent studies have shown the promising role of SIRT6 in mammalian aging and skeletal tissue health, however its role in the intervertebral disc health remains unexplored. We investigated the contribution of SIRT6 to disc health by studying the age-dependent spinal phenotype of mice with conditional deletion of Sirt6 in the disc (Acan<sup>CreERT2</sup>; Sirt6<sup>fl/fl</sup>). Histological studies showed a degenerative phenotype in knockout mice compared to Sirt6<sup>fl/fl</sup> control mice at 12 months, which became pronounced at 24 months. RNA-Seq analysis of NP and AF tissue","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-01T10:24:26.353Z","creation":"2026-04-08T11:29:19.907Z"},"accession":"S-EPMC12059161","cross_references":{"pubmed":["40335469"],"doi":["10.1038/s41413-025-00422-3"]}}