{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Tuan Huynh A"],"pubmed_abstract":["<h4>Background</h4>Resistant hypertension (RH) presents significant clinical challenges, often precipitating a spectrum of cardiovascular complications. Particular attention recently has focused on the role of matrix metalloproteinase-2 (MMP-2) gene polymorphisms, implicated in hypertensive target organ damage (TOD). Despite growing interest, the specific contribution of MMP-2 polymorphisms to such damage in RH remains inadequately defined.<h4>Objective</h4>This study is the first to examine the rs243865 (-1306C>T) polymorphism in the MMP-2 gene in the Vietnamese population and patients with RH, underscoring its critical role as a genetic determinant of TOD.<h4>Methods</h4>A cross-sectional study with both descriptive and analytical components was conducted with 78 patients with RH at the "],"journal":["JMIR cardio"],"pagination":["e71016"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12061201"],"repository":["biostudies-literature"],"pubmed_title":["The rs243865 Polymorphism in Matrix Metalloproteinase-2 and its Association With Target Organ Damage in Patients With Resistant Hypertension: Cross-Sectional Study."],"pmcid":["PMC12061201"],"pubmed_authors":["Tuan Huynh A","Anh TH","Chuong HQ","Viet Tran A","Vu HA"],"additional_accession":[]},"is_claimable":false,"name":"The rs243865 Polymorphism in Matrix Metalloproteinase-2 and its Association With Target Organ Damage in Patients With Resistant Hypertension: Cross-Sectional Study.","description":"<h4>Background</h4>Resistant hypertension (RH) presents significant clinical challenges, often precipitating a spectrum of cardiovascular complications. Particular attention recently has focused on the role of matrix metalloproteinase-2 (MMP-2) gene polymorphisms, implicated in hypertensive target organ damage (TOD). Despite growing interest, the specific contribution of MMP-2 polymorphisms to such damage in RH remains inadequately defined.<h4>Objective</h4>This study is the first to examine the rs243865 (-1306C>T) polymorphism in the MMP-2 gene in the Vietnamese population and patients with RH, underscoring its critical role as a genetic determinant of TOD.<h4>Methods</h4>A cross-sectional study with both descriptive and analytical components was conducted with 78 patients with RH at the ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-02T13:13:12.327Z","creation":"2025-08-18T09:52:38.586Z"},"accession":"S-EPMC12061201","cross_references":{"pubmed":["40311090"],"doi":["10.2196/71016"]}}