biostudies-literatureUnknown9Tuan Huynh A<h4>Background</h4>Resistant hypertension (RH) presents significant clinical challenges, often precipitating a spectrum of cardiovascular complications. Particular attention recently has focused on the role of matrix metalloproteinase-2 (MMP-2) gene polymorphisms, implicated in hypertensive target organ damage (TOD). Despite growing interest, the specific contribution of MMP-2 polymorphisms to such damage in RH remains inadequately defined.<h4>Objective</h4>This study is the first to examine the rs243865 (-1306C>T) polymorphism in the MMP-2 gene in the Vietnamese population and patients with RH, underscoring its critical role as a genetic determinant of TOD.<h4>Methods</h4>A cross-sectional study with both descriptive and analytical components was conducted with 78 patients with RH at the JMIR cardioe71016https://www.ebi.ac.uk/biostudies/studies/S-EPMC12061201biostudies-literatureThe rs243865 Polymorphism in Matrix Metalloproteinase-2 and its Association With Target Organ Damage in Patients With Resistant Hypertension: Cross-Sectional Study.PMC12061201Tuan Huynh AAnh THChuong HQViet Tran AVu HAfalseThe rs243865 Polymorphism in Matrix Metalloproteinase-2 and its Association With Target Organ Damage in Patients With Resistant Hypertension: Cross-Sectional Study.<h4>Background</h4>Resistant hypertension (RH) presents significant clinical challenges, often precipitating a spectrum of cardiovascular complications. Particular attention recently has focused on the role of matrix metalloproteinase-2 (MMP-2) gene polymorphisms, implicated in hypertensive target organ damage (TOD). Despite growing interest, the specific contribution of MMP-2 polymorphisms to such damage in RH remains inadequately defined.<h4>Objective</h4>This study is the first to examine the rs243865 (-1306C>T) polymorphism in the MMP-2 gene in the Vietnamese population and patients with RH, underscoring its critical role as a genetic determinant of TOD.<h4>Methods</h4>A cross-sectional study with both descriptive and analytical components was conducted with 78 patients with RH at the 2025-01-01T00:00:00Z2025 May2026-06-02T13:13:12.327Z2025-08-18T09:52:38.586ZS-EPMC120612014031109010.2196/71016