{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(1)"],"submitter":["Piechota M"],"funding":["National Science Centre, Poland"],"pubmed_abstract":["Glucocorticoids, acting through the glucocorticoid receptor (GR), control metabolism, maintain homeostasis, and enable adaptive responses to environmental challenges. Their function has been comprehensively studied, leading to identification of numerous tissue-specific GR-dependent mechanisms. Abundant evidence shows that GR-triggered responses differ across tissues, however, the extent of this specificity was not comprehensively explored. It is also unknown how particular GR-induced molecular patterns are translated into profile of higher-level human traits. Here, we examine cross-tissue effects of GR activation on gene expression. We assessed changes induced by stimulation with GR agonist, dexamethasone in nine tissues (adrenal cortex, perigonadal adipose tissue, hypothalamus, liver, kid"],"journal":["BMC genomics"],"pagination":["462"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12063231"],"repository":["biostudies-literature"],"pubmed_title":["A cross-tissue transcriptomic approach decodes glucocorticoid receptor-dependent links to human metabolic phenotypes."],"pmcid":["PMC12063231"],"pubmed_authors":["Skupio U","Golda S","Hajto J","Slezak M","Piechota M","Borczyk M","Zieba M","Korostynski M","Parkitna JR"],"additional_accession":[]},"is_claimable":false,"name":"A cross-tissue transcriptomic approach decodes glucocorticoid receptor-dependent links to human metabolic phenotypes.","description":"Glucocorticoids, acting through the glucocorticoid receptor (GR), control metabolism, maintain homeostasis, and enable adaptive responses to environmental challenges. Their function has been comprehensively studied, leading to identification of numerous tissue-specific GR-dependent mechanisms. Abundant evidence shows that GR-triggered responses differ across tissues, however, the extent of this specificity was not comprehensively explored. It is also unknown how particular GR-induced molecular patterns are translated into profile of higher-level human traits. Here, we examine cross-tissue effects of GR activation on gene expression. We assessed changes induced by stimulation with GR agonist, dexamethasone in nine tissues (adrenal cortex, perigonadal adipose tissue, hypothalamus, liver, kid","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-04-15T03:25:51.648Z","creation":"2026-04-15T03:15:19.064Z"},"accession":"S-EPMC12063231","cross_references":{"pubmed":["40346507"],"doi":["10.1186/s12864-025-11676-w"]}}