biostudies-literatureUnknown26(1)Piechota MNational Science Centre, PolandGlucocorticoids, acting through the glucocorticoid receptor (GR), control metabolism, maintain homeostasis, and enable adaptive responses to environmental challenges. Their function has been comprehensively studied, leading to identification of numerous tissue-specific GR-dependent mechanisms. Abundant evidence shows that GR-triggered responses differ across tissues, however, the extent of this specificity was not comprehensively explored. It is also unknown how particular GR-induced molecular patterns are translated into profile of higher-level human traits. Here, we examine cross-tissue effects of GR activation on gene expression. We assessed changes induced by stimulation with GR agonist, dexamethasone in nine tissues (adrenal cortex, perigonadal adipose tissue, hypothalamus, liver, kidBMC genomics462https://www.ebi.ac.uk/biostudies/studies/S-EPMC12063231biostudies-literatureA cross-tissue transcriptomic approach decodes glucocorticoid receptor-dependent links to human metabolic phenotypes.PMC12063231Skupio UGolda SHajto JSlezak MPiechota MBorczyk MZieba MKorostynski MParkitna JRfalseA cross-tissue transcriptomic approach decodes glucocorticoid receptor-dependent links to human metabolic phenotypes.Glucocorticoids, acting through the glucocorticoid receptor (GR), control metabolism, maintain homeostasis, and enable adaptive responses to environmental challenges. Their function has been comprehensively studied, leading to identification of numerous tissue-specific GR-dependent mechanisms. Abundant evidence shows that GR-triggered responses differ across tissues, however, the extent of this specificity was not comprehensively explored. It is also unknown how particular GR-induced molecular patterns are translated into profile of higher-level human traits. Here, we examine cross-tissue effects of GR activation on gene expression. We assessed changes induced by stimulation with GR agonist, dexamethasone in nine tissues (adrenal cortex, perigonadal adipose tissue, hypothalamus, liver, kid2025-01-01T00:00:00Z2025 May2026-04-15T03:25:51.648Z2026-04-15T03:15:19.064ZS-EPMC120632314034650710.1186/s12864-025-11676-w