{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang J"],"funding":["S&T program of Hebei","Clinical Research and Innovation Team Support Program of Hebei Medical University","Medical Science Research Project of Hebei","S&amp;T program of Hebei"],"pagination":["141"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12063428"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(1)"],"pubmed_abstract":["<h4>Background</h4>Tumors often evade immune surveillance by limiting T cell infiltration. In non-small cell lung cancer (NSCLC), increased infiltration of CD8<sup>+</sup> T cells is associated with a favorable response to immunotherapy. While BIN1 is recognized as a tumor suppressor gene, its role in shaping the tumor microenvironment in NSCLC has yet to be fully clarified.<h4>Methods</h4>To investigate the relationship between BIN1 expression and CD8<sup>+</sup>T cell infiltration in NSCLC, we performed a comprehensive data analysis utilizing clinical information from NSCLC patients. BIN1 expression levels in NSCLC tissues were evaluated, and their correlation with CD8<sup>+</sup>T cells infiltration and patient survival outcomes was examined. Loss-of-function strategies targeting BIN1 w"],"journal":["Journal of experimental & clinical cancer research : CR"],"pubmed_title":["Tumor cell-intrinsic BIN1 deficiency promotes the immunosuppression and impedes ferroptosis of non-small cell lung cancer via G3BP1-mediated degradation of STAT1."],"pmcid":["PMC12063428"],"funding_grant_id":["20210168","2022LCTD-A11","H2024206222"],"pubmed_authors":["Liu X","Liu L","Chen J","Yin S","Zhang Y","Jia Y","Liu T","Xu X","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"Tumor cell-intrinsic BIN1 deficiency promotes the immunosuppression and impedes ferroptosis of non-small cell lung cancer via G3BP1-mediated degradation of STAT1.","description":"<h4>Background</h4>Tumors often evade immune surveillance by limiting T cell infiltration. In non-small cell lung cancer (NSCLC), increased infiltration of CD8<sup>+</sup> T cells is associated with a favorable response to immunotherapy. While BIN1 is recognized as a tumor suppressor gene, its role in shaping the tumor microenvironment in NSCLC has yet to be fully clarified.<h4>Methods</h4>To investigate the relationship between BIN1 expression and CD8<sup>+</sup>T cell infiltration in NSCLC, we performed a comprehensive data analysis utilizing clinical information from NSCLC patients. BIN1 expression levels in NSCLC tissues were evaluated, and their correlation with CD8<sup>+</sup>T cells infiltration and patient survival outcomes was examined. Loss-of-function strategies targeting BIN1 w","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-02T13:12:00.814Z","creation":"2026-04-18T03:11:30.898Z"},"accession":"S-EPMC12063428","cross_references":{"pubmed":["40346580"],"doi":["10.1186/s13046-025-03404-9"]}}