biostudies-literatureWang JS&T program of HebeiClinical Research and Innovation Team Support Program of Hebei Medical UniversityMedical Science Research Project of HebeiS&amp;T program of Hebei141https://www.ebi.ac.uk/biostudies/studies/S-EPMC12063428biostudies-literatureUnknown44(1)<h4>Background</h4>Tumors often evade immune surveillance by limiting T cell infiltration. In non-small cell lung cancer (NSCLC), increased infiltration of CD8⁺ T cells is associated with a favorable response to immunotherapy. While BIN1 is recognized as a tumor suppressor gene, its role in shaping the tumor microenvironment in NSCLC has yet to be fully clarified.<h4>Methods</h4>To investigate the relationship between BIN1 expression and CD8⁺T cell infiltration in NSCLC, we performed a comprehensive data analysis utilizing clinical information from NSCLC patients. BIN1 expression levels in NSCLC tissues were evaluated, and their correlation with CD8⁺T cells infiltration and patient survival outcomes was examined. Loss-of-function strategies targeting BIN1 wJournal of experimental & clinical cancer research : CRTumor cell-intrinsic BIN1 deficiency promotes the immunosuppression and impedes ferroptosis of non-small cell lung cancer via G3BP1-mediated degradation of STAT1.PMC12063428202101682022LCTD-A11H2024206222Liu XLiu LChen JYin SZhang YJia YLiu TXu XWang JfalseTumor cell-intrinsic BIN1 deficiency promotes the immunosuppression and impedes ferroptosis of non-small cell lung cancer via G3BP1-mediated degradation of STAT1.<h4>Background</h4>Tumors often evade immune surveillance by limiting T cell infiltration. In non-small cell lung cancer (NSCLC), increased infiltration of CD8⁺ T cells is associated with a favorable response to immunotherapy. While BIN1 is recognized as a tumor suppressor gene, its role in shaping the tumor microenvironment in NSCLC has yet to be fully clarified.<h4>Methods</h4>To investigate the relationship between BIN1 expression and CD8⁺T cell infiltration in NSCLC, we performed a comprehensive data analysis utilizing clinical information from NSCLC patients. BIN1 expression levels in NSCLC tissues were evaluated, and their correlation with CD8⁺T cells infiltration and patient survival outcomes was examined. Loss-of-function strategies targeting BIN1 w2025-01-01T00:00:00Z2025 May2026-06-02T13:12:00.814Z2026-04-18T03:11:30.898ZS-EPMC120634284034658010.1186/s13046-025-03404-9