{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jardon KM"],"funding":["TiFN"],"pagination":["2501185"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12064058"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Insulin resistance (IR) is an early marker of cardiometabolic deterioration which may develop heterogeneously in key metabolic organs, including the liver (LIR) and skeletal muscle (MIR). This tissue-specific IR is characterized by distinct metabolic signatures, but the role of the gut microbiota in its etiology remains unclear. Here, we profiled the gut microbiota, its metabolites and the plasma metabolome in individuals with either a LIR or MIR phenotype (<i>n</i> = 233). We observed distinct microbial community structures LIR and MIR, and higher short-chain fatty acid (SCFA) producing bacteria, fecal SCFAs and branched-chain fatty acids and a higher postprandial plasma glucagon-like-peptide-1 response in LIR. In addition, we found variations in metabolome profiles and phenotype-specific"],"journal":["Gut microbes"],"pubmed_title":["Distinct gut microbiota and metabolome features of tissue-specific insulin resistance in overweight and obesity."],"pmcid":["PMC12064058"],"funding_grant_id":["16NH04"],"pubmed_authors":["Hul GB","Blaak EE","Siebelink E","Jardon KM","Trouwborst I","Bastings JJAJ","Umanets A","Afman LA","Chenal E","Gijbels A","Venema K","Argamasilla R","Vliex LMM","Goossens GH"],"additional_accession":[]},"is_claimable":false,"name":"Distinct gut microbiota and metabolome features of tissue-specific insulin resistance in overweight and obesity.","description":"Insulin resistance (IR) is an early marker of cardiometabolic deterioration which may develop heterogeneously in key metabolic organs, including the liver (LIR) and skeletal muscle (MIR). This tissue-specific IR is characterized by distinct metabolic signatures, but the role of the gut microbiota in its etiology remains unclear. Here, we profiled the gut microbiota, its metabolites and the plasma metabolome in individuals with either a LIR or MIR phenotype (<i>n</i> = 233). We observed distinct microbial community structures LIR and MIR, and higher short-chain fatty acid (SCFA) producing bacteria, fecal SCFAs and branched-chain fatty acids and a higher postprandial plasma glucagon-like-peptide-1 response in LIR. In addition, we found variations in metabolome profiles and phenotype-specific","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-01T18:04:47.08Z","creation":"2026-05-19T03:07:11.544Z"},"accession":"S-EPMC12064058","cross_references":{"pubmed":["40336254"],"doi":["10.1080/19490976.2025.2501185"]}}