{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bhattacharyya J"],"funding":["National Institute on Aging at the National Institutes of Health","NIA NIH HHS"],"pagination":["e70200"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12069012"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(5)"],"pubmed_abstract":["<h4>Introduction</h4>US Medicare claims can be used to identify dementia cases for research. Our objective was to evaluate the performance of International Classification of Diseases, 10th Revision (ICD-10) code definitions versus research-based dementia ascertainment.<h4>Methods</h4>Participants of five Rush Alzheimer's Disease Center (RADC) cohorts with study visits between October 2015 and December 2019 and fee-for-service Medicare contributed observations. For each observation, we compared research-based dementia status to dementia status based on six ICD-10 code definitions.<h4>Results</h4>A total of 1869 participants contributed 5309 observations (mean age 82.9 years, 21.0% Black, 9.3% met research-based dementia criteria). The accuracy of ICD-10 code definitions was high (87%-90%); five of six code definitions favored specificity over sensitivity. All ICD-10 code definitions were less accurate among subgroups defined by older age, minoritized race, increased depressive symptoms, and history of stroke.<h4>Discussion</h4>Performance of ICD-10 code definitions mirrored that of ICD-9 code definitions. Awareness of differential performance by participant characteristics can improve the robustness of research.<h4>Highlights</h4>We report the performance of the International Classification of Diseases, 10th Revision (ICD-10) code versus research-based dementia ascertainment. ICD-10 performed worse with age, depressive symptoms, minoritized race, and stroke. Awareness of accuracy and differential performance can improve research robustness."],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Evaluating linked ICD-10 Medicare claims data as a method of dementia case ascertainment in research settings."],"pmcid":["PMC12069012"],"funding_grant_id":["P30AG72975","P30 AG072975","R01 AG079226","R01 AG072559","RO1AG075730","5R01AG072559","R01 AG022018","R01AG22018","R01AG79226","R01 AG017917","R01 AG075730","R01AG17917"],"pubmed_authors":["Barnes LL","Gianattasio KZ","Prather C","Marquez DX","James BD","Grodstein F","Bhattacharyya J","Rein DB","Moghtaderi A","Shah RC","Power MC","Chen Y","Stapp EK"],"additional_accession":[]},"is_claimable":false,"name":"Evaluating linked ICD-10 Medicare claims data as a method of dementia case ascertainment in research settings.","description":"<h4>Introduction</h4>US Medicare claims can be used to identify dementia cases for research. Our objective was to evaluate the performance of International Classification of Diseases, 10th Revision (ICD-10) code definitions versus research-based dementia ascertainment.<h4>Methods</h4>Participants of five Rush Alzheimer's Disease Center (RADC) cohorts with study visits between October 2015 and December 2019 and fee-for-service Medicare contributed observations. For each observation, we compared research-based dementia status to dementia status based on six ICD-10 code definitions.<h4>Results</h4>A total of 1869 participants contributed 5309 observations (mean age 82.9 years, 21.0% Black, 9.3% met research-based dementia criteria). The accuracy of ICD-10 code definitions was high (87%-90%); five of six code definitions favored specificity over sensitivity. All ICD-10 code definitions were less accurate among subgroups defined by older age, minoritized race, increased depressive symptoms, and history of stroke.<h4>Discussion</h4>Performance of ICD-10 code definitions mirrored that of ICD-9 code definitions. Awareness of differential performance by participant characteristics can improve the robustness of research.<h4>Highlights</h4>We report the performance of the International Classification of Diseases, 10th Revision (ICD-10) code versus research-based dementia ascertainment. ICD-10 performed worse with age, depressive symptoms, minoritized race, and stroke. Awareness of accuracy and differential performance can improve research robustness.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-06T23:40:24.218Z","creation":"2026-06-06T03:11:00.73Z"},"accession":"S-EPMC12069012","cross_references":{"pubmed":["40356037"],"doi":["10.1002/alz.70200"]}}