{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(3)"],"submitter":["Guo M"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["The liver regenerative capacity is crucial for patients with end-stage liver disease following partial hepatectomy (PHx). The specific bacteria and mechanisms regulating liver regeneration post-PHx remain unclear. This study demonstrated dynamic changes in the abundance of <i>Parabacteroides distasonis</i> (<i>P. distasonis</i>) post-PHx, correlating with hepatocyte proliferation. Treatment with live <i>P. distasonis</i> significantly promoted hepatocyte proliferation and liver regeneration after PHx. Targeted metabolomics revealed a significant positive correlation between <i>P. distasonis</i> and <i>β</i>-hydroxybutyric acid (BHB), as well as hyodeoxycholic acid and 3-hydroxyphenylacetic acid in the gut after PHx. Notably, treatment with BHB, but not hyodeoxycholic acid or 3-hydroxypheny"],"journal":["Acta pharmaceutica Sinica. B"],"pagination":["1430-1446"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12069244"],"repository":["biostudies-literature"],"pubmed_title":["&lt;i&gt;Parabacteroides distasonis&lt;/i&gt; promotes liver regeneration by increasing &lt;i&gt;β&lt;/i&gt;-hydroxybutyric acid (BHB) production and BHB-driven STAT3 signals."],"pmcid":["PMC12069244"],"pubmed_authors":["Chen P","Zhou W","Zhang S","Fan S","Yang X","Bi H","Guo M","Bi G","Wang P","Liang F","Ouyang H","Jiang X","Zhang X","Wu T","Fang JH"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Parabacteroides distasonis&lt;/i&gt; promotes liver regeneration by increasing &lt;i&gt;β&lt;/i&gt;-hydroxybutyric acid (BHB) production and BHB-driven STAT3 signals.","description":"The liver regenerative capacity is crucial for patients with end-stage liver disease following partial hepatectomy (PHx). The specific bacteria and mechanisms regulating liver regeneration post-PHx remain unclear. This study demonstrated dynamic changes in the abundance of <i>Parabacteroides distasonis</i> (<i>P. distasonis</i>) post-PHx, correlating with hepatocyte proliferation. Treatment with live <i>P. distasonis</i> significantly promoted hepatocyte proliferation and liver regeneration after PHx. Targeted metabolomics revealed a significant positive correlation between <i>P. distasonis</i> and <i>β</i>-hydroxybutyric acid (BHB), as well as hyodeoxycholic acid and 3-hydroxyphenylacetic acid in the gut after PHx. Notably, treatment with BHB, but not hyodeoxycholic acid or 3-hydroxypheny","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-03T02:45:24.146Z","creation":"2026-04-23T03:11:16.389Z"},"accession":"S-EPMC12069244","cross_references":{"pubmed":["40370533"],"doi":["10.1016/j.apsb.2025.01.024"]}}