{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Han C"],"pubmed_abstract":["In <i>Saccharomyces cerevisiae</i>, Atg1 is a core autophagy-related (Atg) protein kinase (PK) in regulating macroautophagy/autophagy, by physically interacting with numerous other proteins, or by phosphorylating various substrates. It is unclear how many Atg1-interacting partners and substrates are also involved in regulating autophagy. Here, we conducted transcriptomic, proteomic and phosphoproteomic profiling of Atg1-dependent molecular landscapes during nitrogen starvation-triggered autophagy, and detected 244, 245 and 217 genes to be affected by <i>ATG1</i> in the autophagic process at mRNA, protein, and phosphorylation levels, respectively. Based on the Atg1 interactome, we developed a novel artificial intelligence (AI) framework, inference of autophagy regulators from multi-omic dat"],"journal":["Frontiers in cell and developmental biology"],"pagination":["1554958"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12069372"],"repository":["biostudies-literature"],"pubmed_title":["Omic AI reveals new autophagy regulators from the Atg1 interactome in &lt;i&gt;Saccharomyces cerevisiae&lt;/i&gt;."],"pmcid":["PMC12069372"],"pubmed_authors":["Fu S","Feng Z","Zhang J","Tang D","Xue Y","Zhang W","Xiao L","Peng D","Yi C","Chen Y","Gou Y","Han C","Liu D","Zhang C"],"additional_accession":[]},"is_claimable":false,"name":"Omic AI reveals new autophagy regulators from the Atg1 interactome in &lt;i&gt;Saccharomyces cerevisiae&lt;/i&gt;.","description":"In <i>Saccharomyces cerevisiae</i>, Atg1 is a core autophagy-related (Atg) protein kinase (PK) in regulating macroautophagy/autophagy, by physically interacting with numerous other proteins, or by phosphorylating various substrates. It is unclear how many Atg1-interacting partners and substrates are also involved in regulating autophagy. Here, we conducted transcriptomic, proteomic and phosphoproteomic profiling of Atg1-dependent molecular landscapes during nitrogen starvation-triggered autophagy, and detected 244, 245 and 217 genes to be affected by <i>ATG1</i> in the autophagic process at mRNA, protein, and phosphorylation levels, respectively. Based on the Atg1 interactome, we developed a novel artificial intelligence (AI) framework, inference of autophagy regulators from multi-omic dat","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-04-18T03:15:45.252Z","creation":"2026-04-18T03:11:03.788Z"},"accession":"S-EPMC12069372","cross_references":{"pubmed":["40365021"],"doi":["10.3389/fcell.2025.1554958"]}}