{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wagh R"],"funding":["Department of Science and Technology, India","Crafoordska Stiftelsen","Director Albert Påhlsson stiftelse","Vetenskapsrådet","Åke Wiberg Stiftelse","Medical Research Council","Heart Lung Foundation","Lund University","Wellcome Trust","VINNOVA","Hjelt Foundation","Department of Biotechnology, Ministry of Science and Technology, India"],"pagination":["1298-1314"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12069499"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["68(6)"],"pubmed_abstract":["Aims/hypothesis
Cardiometabolic traits are heritable, and some display parent-of-origin effects, which indicates preferential inheritance from one parent or parental bias. Most studies of these phenomena have focused on adult populations. We aimed to investigate the heritability and parent-of-origin effects on cardiometabolic traits in a birth cohort with serial measurements to determine whether these patterns emerged early in life.Methods
The Pune Maternal Nutrition Study comprises a birth cohort in which offspring and parents were studied from birth and followed up for 24 years. We investigated parent-of-origin effects on cardiometabolic traits cross-sectionally at available timepoints using linear regression, and longitudinally across the life course using mixed-effect r"],"journal":["Diabetologia"],"pubmed_title":["Parent-of-origin effects in the life-course evolution of cardiometabolic traits."],"pmcid":["PMC12069499"],"funding_grant_id":["MR/J000094/1","059609","20180522","083460/Z/07/Z","038128/Z/93","M20-0214","2023-04234","BT/PR-6870/PID/20/268/2005","20200891","038128","C/3019/IFD/2018-2019","059609/Z/99","098575/B/12/Z","2021-02623","079877/Z/06/Z","2015-06722"],"pubmed_authors":["Wagh R","Hatem G","Andersson J","Bandyopadhyay S","Kunte P","Yajnik CS","Prasad RB"],"additional_accession":[]},"is_claimable":false,"name":"Parent-of-origin effects in the life-course evolution of cardiometabolic traits.","description":"Aims/hypothesis
Cardiometabolic traits are heritable, and some display parent-of-origin effects, which indicates preferential inheritance from one parent or parental bias. Most studies of these phenomena have focused on adult populations. We aimed to investigate the heritability and parent-of-origin effects on cardiometabolic traits in a birth cohort with serial measurements to determine whether these patterns emerged early in life.Methods
The Pune Maternal Nutrition Study comprises a birth cohort in which offspring and parents were studied from birth and followed up for 24 years. We investigated parent-of-origin effects on cardiometabolic traits cross-sectionally at available timepoints using linear regression, and longitudinally across the life course using mixed-effect r","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-01T10:24:57.596Z","creation":"2026-04-08T11:21:36.613Z"},"accession":"S-EPMC12069499","cross_references":{"pubmed":["40175764"],"doi":["10.1007/s00125-025-06396-5"]}}