biostudies-literatureWagh RDepartment of Science and Technology, IndiaCrafoordska StiftelsenDirector Albert Påhlsson stiftelseVetenskapsrådetÅke Wiberg StiftelseMedical Research CouncilHeart Lung FoundationLund UniversityWellcome TrustVINNOVAHjelt FoundationDepartment of Biotechnology, Ministry of Science and Technology, India1298-1314https://www.ebi.ac.uk/biostudies/studies/S-EPMC12069499biostudies-literatureUnknown68(6)<h4>Aims/hypothesis</h4>Cardiometabolic traits are heritable, and some display parent-of-origin effects, which indicates preferential inheritance from one parent or parental bias. Most studies of these phenomena have focused on adult populations. We aimed to investigate the heritability and parent-of-origin effects on cardiometabolic traits in a birth cohort with serial measurements to determine whether these patterns emerged early in life.<h4>Methods</h4>The Pune Maternal Nutrition Study comprises a birth cohort in which offspring and parents were studied from birth and followed up for 24 years. We investigated parent-of-origin effects on cardiometabolic traits cross-sectionally at available timepoints using linear regression, and longitudinally across the life course using mixed-effect rDiabetologiaParent-of-origin effects in the life-course evolution of cardiometabolic traits.PMC12069499MR/J000094/105960920180522083460/Z/07/Z038128/Z/93M20-02142023-04234BT/PR-6870/PID/20/268/200520200891038128C/3019/IFD/2018-2019059609/Z/99098575/B/12/Z2021-02623079877/Z/06/Z2015-06722Wagh RHatem GAndersson JBandyopadhyay SKunte PYajnik CSPrasad RBfalseParent-of-origin effects in the life-course evolution of cardiometabolic traits.<h4>Aims/hypothesis</h4>Cardiometabolic traits are heritable, and some display parent-of-origin effects, which indicates preferential inheritance from one parent or parental bias. Most studies of these phenomena have focused on adult populations. We aimed to investigate the heritability and parent-of-origin effects on cardiometabolic traits in a birth cohort with serial measurements to determine whether these patterns emerged early in life.<h4>Methods</h4>The Pune Maternal Nutrition Study comprises a birth cohort in which offspring and parents were studied from birth and followed up for 24 years. We investigated parent-of-origin effects on cardiometabolic traits cross-sectionally at available timepoints using linear regression, and longitudinally across the life course using mixed-effect r2025-01-01T00:00:00Z2025 Jun2026-06-01T10:24:57.596Z2026-04-08T11:21:36.613ZS-EPMC120694994017576410.1007/s00125-025-06396-5