{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dillman JR"],"funding":["The Leona M. and Harry B. Helmsley Charitable Trust","NIDDK NIH HHS","NIH HHS"],"pagination":["1380-1391"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12069992"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(5)"],"pubmed_abstract":["<h4>Background</h4>We previously identified circulating and MRI biomarkers associated with the surgical management of Crohn's disease (CD). Here we tested associations between these biomarkers and ileal resection inflammation and collagen content.<h4>Methods</h4>Fifty CD patients undergoing ileal resection were prospectively enrolled at 4 centers. Circulating CD64, extracellular matrix protein 1 (ECM1), GM-CSF autoantibodies (GM-CSF Ab), and fecal calprotectin were measured by ELISA. Ileal 3-dimensional magnetization transfer ratio (3D MTR), modified Look-Locker inversion recovery (MOLLI) T1 relaxation, diffusion-weighted intravoxel incoherent motion (IVIM), and the simplified magnetic resonance index of activity (sMaRIA) were measured by MRI. Ileal resection specimen acute inflammation wa"],"journal":["Inflammatory bowel diseases"],"pubmed_title":["Circulating and Magnetic Resonance Imaging Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease."],"pmcid":["PMC12069992"],"funding_grant_id":["P30 DK078392"],"pubmed_authors":["Jurrell H","Anton CG","Trapnell BC","Fletcher JG","Bruining DH","Denson LA","Dillman JR","Kugathasan S","Imbus RA","Towbin AJ","Lopez-Nunez O","Dudley JA","Adler J","Fei L","Collins MH","Tkach JA","Lu A","Stidham RW","Bonkowski EL","Alazraki AL","Knight-Scott J","Kocaoglu M","Swanson SD","Minar P","Qian L"],"additional_accession":[]},"is_claimable":false,"name":"Circulating and Magnetic Resonance Imaging Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease.","description":"<h4>Background</h4>We previously identified circulating and MRI biomarkers associated with the surgical management of Crohn's disease (CD). Here we tested associations between these biomarkers and ileal resection inflammation and collagen content.<h4>Methods</h4>Fifty CD patients undergoing ileal resection were prospectively enrolled at 4 centers. Circulating CD64, extracellular matrix protein 1 (ECM1), GM-CSF autoantibodies (GM-CSF Ab), and fecal calprotectin were measured by ELISA. Ileal 3-dimensional magnetization transfer ratio (3D MTR), modified Look-Locker inversion recovery (MOLLI) T1 relaxation, diffusion-weighted intravoxel incoherent motion (IVIM), and the simplified magnetic resonance index of activity (sMaRIA) were measured by MRI. Ileal resection specimen acute inflammation wa","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-06T21:39:44.701Z","creation":"2026-06-05T03:11:52.908Z"},"accession":"S-EPMC12069992","cross_references":{"pubmed":["39853252"],"doi":["10.1093/ibd/izae319"]}}