biostudies-literatureDillman JRThe Leona M. and Harry B. Helmsley Charitable TrustNIDDK NIH HHSNIH HHS1380-1391https://www.ebi.ac.uk/biostudies/studies/S-EPMC12069992biostudies-literatureUnknown31(5)<h4>Background</h4>We previously identified circulating and MRI biomarkers associated with the surgical management of Crohn's disease (CD). Here we tested associations between these biomarkers and ileal resection inflammation and collagen content.<h4>Methods</h4>Fifty CD patients undergoing ileal resection were prospectively enrolled at 4 centers. Circulating CD64, extracellular matrix protein 1 (ECM1), GM-CSF autoantibodies (GM-CSF Ab), and fecal calprotectin were measured by ELISA. Ileal 3-dimensional magnetization transfer ratio (3D MTR), modified Look-Locker inversion recovery (MOLLI) T1 relaxation, diffusion-weighted intravoxel incoherent motion (IVIM), and the simplified magnetic resonance index of activity (sMaRIA) were measured by MRI. Ileal resection specimen acute inflammation waInflammatory bowel diseasesCirculating and Magnetic Resonance Imaging Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease.PMC12069992P30 DK078392Jurrell HAnton CGTrapnell BCFletcher JGBruining DHDenson LADillman JRKugathasan SImbus RATowbin AJLopez-Nunez ODudley JAAdler JFei LCollins MHTkach JALu AStidham RWBonkowski ELAlazraki ALKnight-Scott JKocaoglu MSwanson SDMinar PQian LfalseCirculating and Magnetic Resonance Imaging Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease.<h4>Background</h4>We previously identified circulating and MRI biomarkers associated with the surgical management of Crohn's disease (CD). Here we tested associations between these biomarkers and ileal resection inflammation and collagen content.<h4>Methods</h4>Fifty CD patients undergoing ileal resection were prospectively enrolled at 4 centers. Circulating CD64, extracellular matrix protein 1 (ECM1), GM-CSF autoantibodies (GM-CSF Ab), and fecal calprotectin were measured by ELISA. Ileal 3-dimensional magnetization transfer ratio (3D MTR), modified Look-Locker inversion recovery (MOLLI) T1 relaxation, diffusion-weighted intravoxel incoherent motion (IVIM), and the simplified magnetic resonance index of activity (sMaRIA) were measured by MRI. Ileal resection specimen acute inflammation wa2025-01-01T00:00:00Z2025 May2026-06-06T21:39:44.701Z2026-06-05T03:11:52.908ZS-EPMC120699923985325210.1093/ibd/izae319