{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qiao H"],"funding":["National Natural Science Foundation of China"],"pagination":["4165"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12072170"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(9)"],"pubmed_abstract":["The Rare Cold-Inducible 2 (<i>RCI2</i>) gene encodes a conserved hydrophobic peptide that plays a crucial role in ion homeostasis, membrane stability, and responses to abiotic stress. In this study, six members of the <i>MsRCI2</i> gene family were identified in <i>Medicago sativa</i> L., all of which contain highly conserved PMP<sub>3</sub> domains. Comparative collinearity analysis revealed syntenic relationships between <i>M. sativa</i> and <i>M. truncatula</i>, with each gene displaying distinct expression profiles under various stress conditions. Among them, <i>MsRCI2B</i> was significantly upregulated in response to salt stress. Alfalfa plants overexpressing <i>MsRCI2B</i> exhibited enhanced salt tolerance, as evidenced by increased antioxidant enzyme activities and reduced accumulat"],"journal":["International journal of molecular sciences"],"pubmed_title":["Genome-Wide Analysis of the &lt;i&gt;MsRCI2&lt;/i&gt; Gene Family in &lt;i&gt;Medicago sativa&lt;/i&gt; and Functional Characterization of &lt;i&gt;MsRCI2B&lt;/i&gt; in Salt Tolerance."],"pmcid":["PMC12072170"],"funding_grant_id":["32071866"],"pubmed_authors":["Li Y","Qiao H","Zhang D","Zhang Z","Meng J","Zhang S","Wang Y","Cai H","He P"],"additional_accession":[]},"is_claimable":false,"name":"Genome-Wide Analysis of the &lt;i&gt;MsRCI2&lt;/i&gt; Gene Family in &lt;i&gt;Medicago sativa&lt;/i&gt; and Functional Characterization of &lt;i&gt;MsRCI2B&lt;/i&gt; in Salt Tolerance.","description":"The Rare Cold-Inducible 2 (<i>RCI2</i>) gene encodes a conserved hydrophobic peptide that plays a crucial role in ion homeostasis, membrane stability, and responses to abiotic stress. In this study, six members of the <i>MsRCI2</i> gene family were identified in <i>Medicago sativa</i> L., all of which contain highly conserved PMP<sub>3</sub> domains. Comparative collinearity analysis revealed syntenic relationships between <i>M. sativa</i> and <i>M. truncatula</i>, with each gene displaying distinct expression profiles under various stress conditions. Among them, <i>MsRCI2B</i> was significantly upregulated in response to salt stress. Alfalfa plants overexpressing <i>MsRCI2B</i> exhibited enhanced salt tolerance, as evidenced by increased antioxidant enzyme activities and reduced accumulat","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-05-21T03:23:13.59Z","creation":"2026-05-21T03:08:52.482Z"},"accession":"S-EPMC12072170","cross_references":{"pubmed":["40362404"],"doi":["10.3390/ijms26094165"]}}