{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wing A"],"funding":["NEI NIH HHS","NIDDK NIH HHS","NCI NIH HHS","NIH HHS"],"pagination":["115527"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12073628"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(4)"],"pubmed_abstract":["Dietary fat composition has changed substantially during the obesity epidemic. As adipocyte hyperplasia is a major mechanism of adipose expansion, we aim to ascertain how dietary fats affect adipogenesis during obesity. We employ an unbiased dietary screen to identify oleic acid (OA) as the only dietary fatty acid that induces obesogenic hyperplasia at physiologic levels and show that plasma monounsaturated fatty acids (MUFAs), which are mostly OA, are associated with human obesity. OA stimulates adipogenesis in mouse and human adipocyte precursor cells (APCs) by increasing AKT2 signaling, a hallmark of obesogenic hyperplasia, and reducing LXR activity. High OA consumption decreases LXRα Ser196 phosphorylation in APCs, while blocking LXRα phosphorylation results in APC hyperproliferation. "],"journal":["Cell reports"],"pubmed_title":["Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling."],"pmcid":["PMC12073628"],"funding_grant_id":["S10 OD030363","R56 DK090489","R01 DK110147","R01 DK090489","R01 DK126447","S10 OD026996","P30 CA016359","R01 DK132563","F31 EY034776"],"pubmed_authors":["Floody M","Rodeheffer MS","Goodell J","Saavedra-Pena RDM","Holtrup B","Varshney R","Jeffery E","Zapadka TE","Rudolph MC","Wing A","Church CD","Saha M","Wang Z","Voisin M","Alavi NS","Garabedian MJ"],"additional_accession":[]},"is_claimable":false,"name":"Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling.","description":"Dietary fat composition has changed substantially during the obesity epidemic. As adipocyte hyperplasia is a major mechanism of adipose expansion, we aim to ascertain how dietary fats affect adipogenesis during obesity. We employ an unbiased dietary screen to identify oleic acid (OA) as the only dietary fatty acid that induces obesogenic hyperplasia at physiologic levels and show that plasma monounsaturated fatty acids (MUFAs), which are mostly OA, are associated with human obesity. OA stimulates adipogenesis in mouse and human adipocyte precursor cells (APCs) by increasing AKT2 signaling, a hallmark of obesogenic hyperplasia, and reducing LXR activity. High OA consumption decreases LXRα Ser196 phosphorylation in APCs, while blocking LXRα phosphorylation results in APC hyperproliferation. ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-02T17:59:02.045Z","creation":"2026-04-18T03:12:13.128Z"},"accession":"S-EPMC12073628","cross_references":{"pubmed":["40208790"],"doi":["10.1016/j.celrep.2025.115527"]}}