{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(5)"],"submitter":["Lai X"],"funding":["Academia Sinica"],"pubmed_abstract":["Diguanylate cyclases (DGCs) synthesize bis-(3',5')-cyclic diguanylic acid (c-di-GMP), a critical bacterial second messenger that coordinates diverse biological processes. <i>Agrobacterium tumefaciens</i>, a plant pathogen causing crown gall disease, relies on type IV secretion system for pathogenesis and type VI secretion system (T6SS) for interbacterial competition. Our study identified two putative DGCs, named <u>d</u>iguanylate <u>c</u>yclase domain proteins regulating <u>v</u>irulences A and B (DcvA and DcvB), that negatively regulate virulence through distinct mechanisms. DcvA suppresses virulence by targeting the VirA/VirG two-component system downstream of VirA. This inhibition is independent of c-di-GMP levels. DcvB positively regulates biofilm formation, inhibits T6SS-mediated int"],"journal":["mBio"],"pagination":["e0003925"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12077199"],"repository":["biostudies-literature"],"pubmed_title":["Distinct strategies of diguanylate cyclase domain proteins on inhibition of virulence and interbacterial competition by agrobacteria."],"pmcid":["PMC12077199"],"pubmed_authors":["Lai X","Yu M","Cheng C-P","Lai E-M"],"additional_accession":[]},"is_claimable":false,"name":"Distinct strategies of diguanylate cyclase domain proteins on inhibition of virulence and interbacterial competition by agrobacteria.","description":"Diguanylate cyclases (DGCs) synthesize bis-(3',5')-cyclic diguanylic acid (c-di-GMP), a critical bacterial second messenger that coordinates diverse biological processes. <i>Agrobacterium tumefaciens</i>, a plant pathogen causing crown gall disease, relies on type IV secretion system for pathogenesis and type VI secretion system (T6SS) for interbacterial competition. Our study identified two putative DGCs, named <u>d</u>iguanylate <u>c</u>yclase domain proteins regulating <u>v</u>irulences A and B (DcvA and DcvB), that negatively regulate virulence through distinct mechanisms. DcvA suppresses virulence by targeting the VirA/VirG two-component system downstream of VirA. This inhibition is independent of c-di-GMP levels. DcvB positively regulates biofilm formation, inhibits T6SS-mediated int","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-02T17:59:01.247Z","creation":"2026-04-18T03:12:12.406Z"},"accession":"S-EPMC12077199","cross_references":{"pubmed":["40243313"],"doi":["10.1128/mbio.00039-25"]}}