{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang L"],"funding":["Scientific Research Foundation for the Returned Overseas Chinese Scholars","Technology Innovation Project of Colleges and Universities in Shanxi Province","Medical major Research program of Shanxi","Major Research and Development Program of Shanxi"],"pagination":["16849"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12081695"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly, and the role of chaperonin containing TCP1 subunit 2 (CCT2) remains unclear. This study aims to elucidate the mechanistic link between CCT2 and AMD, contributing to improved understanding and potential therapeutic strategies. Retinal and RPE-Choroid transcriptome array data from 130 AMD patients and 121 normal donors (GSE29801 dataset) were reanalyzed to assess CCT2 expression across different AMD subtypes, age groups, and genders. Single-sample gene set enrichment analysis was performed to explore correlations with autophagy-related genes and other established AMD causes. Additionally, CCT2 expression was validated in sodium iodate (NaIO₃)-induced 661 W cells (photoreceptor-like cells) using quantit"],"journal":["Scientific reports"],"pubmed_title":["Clinical characterization of CCT2 and its role in autophagy regulation during age-related macular degeneration."],"pmcid":["PMC12081695"],"funding_grant_id":["No2020RC22","No. 2020-195","2022L203","No201903D321117"],"pubmed_authors":["Li MY","Zhou GH","Wang LX","Zhang R","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Clinical characterization of CCT2 and its role in autophagy regulation during age-related macular degeneration.","description":"Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly, and the role of chaperonin containing TCP1 subunit 2 (CCT2) remains unclear. This study aims to elucidate the mechanistic link between CCT2 and AMD, contributing to improved understanding and potential therapeutic strategies. Retinal and RPE-Choroid transcriptome array data from 130 AMD patients and 121 normal donors (GSE29801 dataset) were reanalyzed to assess CCT2 expression across different AMD subtypes, age groups, and genders. Single-sample gene set enrichment analysis was performed to explore correlations with autophagy-related genes and other established AMD causes. Additionally, CCT2 expression was validated in sodium iodate (NaIO₃)-induced 661 W cells (photoreceptor-like cells) using quantit","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-04-08T19:52:54.338Z","creation":"2026-04-08T14:31:30.819Z"},"accession":"S-EPMC12081695","cross_references":{"pubmed":["40374738"],"doi":["10.1038/s41598-025-01907-1"]}}