biostudies-literatureBinder EFNIA NIH HHSe2510512https://www.ebi.ac.uk/biostudies/studies/S-EPMC12082367biostudies-literatureUnknown8(5)<h4>Importance</h4>Despite receiving postacute rehabilitation services, many older women with a recent hip fracture repair are unable to return to their prefracture level of function. Whether testosterone therapy can enhance recovery after hip fracture in older women with persistent mobility impairments has not been fully examined.<h4>Objective</h4>To evaluate the effects of a supervised exercise program combined with topical testosterone therapy on functional outcomes in older women with a recent hip fracture.<h4>Design, setting, and participants</h4>This phase 3 double-blind, placebo-controlled randomized clinical trial, Starting a Testosterone and Exercise Program After Hip Injury (STEP-HI), was conducted at 8 US sites between December 2018 and August 2023. Participants were women aged JAMA network openCombining Exercise Training and Testosterone Therapy in Older Women After Hip Fracture: The STEP-HI Randomized Clinical Trial.PMC12082367P30 AG024832R01 AG051647R21 AG023716P30 AG067988R34 AG040257P30 AG028747Binder EFSchechtman KBFisher SRStevens-Lapsley JKiel DPBartley JMMagaziner JSGuild CPaluch RAFortinsky RHBerry SDKuchel GAMcDonough CMReeds DMarcus RLDore PMVolpi EOrwig DLMonroe KMfalseCombining Exercise Training and Testosterone Therapy in Older Women After Hip Fracture: The STEP-HI Randomized Clinical Trial.<h4>Importance</h4>Despite receiving postacute rehabilitation services, many older women with a recent hip fracture repair are unable to return to their prefracture level of function. Whether testosterone therapy can enhance recovery after hip fracture in older women with persistent mobility impairments has not been fully examined.<h4>Objective</h4>To evaluate the effects of a supervised exercise program combined with topical testosterone therapy on functional outcomes in older women with a recent hip fracture.<h4>Design, setting, and participants</h4>This phase 3 double-blind, placebo-controlled randomized clinical trial, Starting a Testosterone and Exercise Program After Hip Injury (STEP-HI), was conducted at 8 US sites between December 2018 and August 2023. Participants were women aged 2025-01-01T00:00:00Z2025 May2026-06-03T02:39:51.451Z2026-04-23T03:11:09.307ZS-EPMC120823674037275210.1001/jamanetworkopen.2025.10512