{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schmid S"],"funding":["Brain Tumour Charity"],"pagination":["1031-1045"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12083230"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(4)"],"pubmed_abstract":["<h4>Background</h4>Intracerebral schwannomas are rare tumors resembling their peripheral nerve sheath counterparts but localized in the central nervous system (CNS). They are not classified as a separate tumor type in the 2021 World Health Organization classification. This study aimed to compile and characterize these rare neoplasms morphologically and molecularly.<h4>Methods</h4>We analyzed 20 tumor samples by histology, RNA next-generation sequencing, DNA-methylation profiling, copy number analyses, and single-nucleus RNA sequencing (snRNA-seq). Clinical data, including age, sex, and disease progression, were collected. Magnetic resonance imaging (MRI) series were included when available.<h4>Results</h4>All cases with tissue available for histology review (n = 13) were morphologically co"],"journal":["Neuro-oncology"],"pubmed_title":["VGLL fusions define a new class of intraparenchymal central nervous system schwannoma."],"pmcid":["PMC12083230"],"funding_grant_id":["GN-000707"],"pubmed_authors":["Liu I","Simon M","Behling F","Stadelmann C","Koch A","Brandner S","Korshunov A","Wesseling P","Mirchia K","Zherebitskiy V","Nuckles J","Snuderl M","Goller P","Siewert C","Coras R","Aldape K","Tietze A","Schittenhelm J","Epari S","Wilson Y","Kaimaktchiev VB","Zechel S","Robinson L","Perera AA","Hartmann C","Jones DTW","Capper D","Perry A","Hernaiz Driever P","Schmid S","Tops BBJ","Sahm F","Hoving EW","Lucas CG","Paine SML","Hasselblatt M","Gianno F"],"additional_accession":[]},"is_claimable":false,"name":"VGLL fusions define a new class of intraparenchymal central nervous system schwannoma.","description":"<h4>Background</h4>Intracerebral schwannomas are rare tumors resembling their peripheral nerve sheath counterparts but localized in the central nervous system (CNS). They are not classified as a separate tumor type in the 2021 World Health Organization classification. This study aimed to compile and characterize these rare neoplasms morphologically and molecularly.<h4>Methods</h4>We analyzed 20 tumor samples by histology, RNA next-generation sequencing, DNA-methylation profiling, copy number analyses, and single-nucleus RNA sequencing (snRNA-seq). Clinical data, including age, sex, and disease progression, were collected. Magnetic resonance imaging (MRI) series were included when available.<h4>Results</h4>All cases with tissue available for histology review (n = 13) were morphologically co","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-04T03:21:20.859Z","creation":"2026-06-04T03:12:56.398Z"},"accession":"S-EPMC12083230","cross_references":{"pubmed":["39713960"],"doi":["10.1093/neuonc/noae269"]}}