biostudies-literatureSchmid SBrain Tumour Charity1031-1045https://www.ebi.ac.uk/biostudies/studies/S-EPMC12083230biostudies-literatureUnknown27(4)<h4>Background</h4>Intracerebral schwannomas are rare tumors resembling their peripheral nerve sheath counterparts but localized in the central nervous system (CNS). They are not classified as a separate tumor type in the 2021 World Health Organization classification. This study aimed to compile and characterize these rare neoplasms morphologically and molecularly.<h4>Methods</h4>We analyzed 20 tumor samples by histology, RNA next-generation sequencing, DNA-methylation profiling, copy number analyses, and single-nucleus RNA sequencing (snRNA-seq). Clinical data, including age, sex, and disease progression, were collected. Magnetic resonance imaging (MRI) series were included when available.<h4>Results</h4>All cases with tissue available for histology review (n = 13) were morphologically coNeuro-oncologyVGLL fusions define a new class of intraparenchymal central nervous system schwannoma.PMC12083230GN-000707Liu ISimon MBehling FStadelmann CKoch ABrandner SKorshunov AWesseling PMirchia KZherebitskiy VNuckles JSnuderl MGoller PSiewert CCoras RAldape KTietze ASchittenhelm JEpari SWilson YKaimaktchiev VBZechel SRobinson LPerera AAHartmann CJones DTWCapper DPerry AHernaiz Driever PSchmid STops BBJSahm FHoving EWLucas CGPaine SMLHasselblatt MGianno FfalseVGLL fusions define a new class of intraparenchymal central nervous system schwannoma.<h4>Background</h4>Intracerebral schwannomas are rare tumors resembling their peripheral nerve sheath counterparts but localized in the central nervous system (CNS). They are not classified as a separate tumor type in the 2021 World Health Organization classification. This study aimed to compile and characterize these rare neoplasms morphologically and molecularly.<h4>Methods</h4>We analyzed 20 tumor samples by histology, RNA next-generation sequencing, DNA-methylation profiling, copy number analyses, and single-nucleus RNA sequencing (snRNA-seq). Clinical data, including age, sex, and disease progression, were collected. Magnetic resonance imaging (MRI) series were included when available.<h4>Results</h4>All cases with tissue available for histology review (n = 13) were morphologically co2025-01-01T00:00:00Z2025 May2026-06-04T03:21:20.859Z2026-06-04T03:12:56.398ZS-EPMC120832303971396010.1093/neuonc/noae269