{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(20)"],"submitter":["Jagadeesan R"],"pubmed_abstract":["Bacterial gene networks have operons, each coordinating several genes under a primary promoter. Half of the operons in <i>Escherichia coli</i> have been reported to also contain internal promoters. We studied their role during genome-wide stresses targeting key transcription regulators, RNA polymerase (RNAP) and gyrase. Our results suggest that operons' responses are influenced by stress-related changes in premature elongation terminations and internal promoters' activity. Globally, this causes the responses of genes in the same operon to differ with the distance between them in a wave-like pattern. Meanwhile, premature terminations are affected by positive supercoiling buildup, collisions between elongating and promoter-bound RNAPs, and local regulatory elements. We report similar finding"],"journal":["Science advances"],"pagination":["eadl3570"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12083536"],"repository":["biostudies-literature"],"pubmed_title":["Dynamics of bacterial operons during genome-wide stresses is influenced by premature terminations and internal promoters."],"pmcid":["PMC12083536"],"pubmed_authors":["Ribeiro AS","Makela J","Dash S","Baptista ISC","Chauhan V","Jagadeesan R","Palma CSD"],"additional_accession":[]},"is_claimable":false,"name":"Dynamics of bacterial operons during genome-wide stresses is influenced by premature terminations and internal promoters.","description":"Bacterial gene networks have operons, each coordinating several genes under a primary promoter. Half of the operons in <i>Escherichia coli</i> have been reported to also contain internal promoters. We studied their role during genome-wide stresses targeting key transcription regulators, RNA polymerase (RNAP) and gyrase. Our results suggest that operons' responses are influenced by stress-related changes in premature elongation terminations and internal promoters' activity. Globally, this causes the responses of genes in the same operon to differ with the distance between them in a wave-like pattern. Meanwhile, premature terminations are affected by positive supercoiling buildup, collisions between elongating and promoter-bound RNAPs, and local regulatory elements. We report similar finding","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-04-08T19:52:43.931Z","creation":"2026-04-08T14:31:26.83Z"},"accession":"S-EPMC12083536","cross_references":{"pubmed":["40378216"],"doi":["10.1126/sciadv.adl3570"]}}