{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Olchanyi MD"],"funding":["NIA NIH HHS","NIMH NIH HHS"],"pubmed_abstract":["Brainstem white matter bundles are essential conduits for neural signaling involved in modulation of vital functions ranging from homeostasis to human consciousness. Their architecture forms the anatomic basis for brainstem connectomics, subcortical mesoscale circuit models, and deep brain navigation tools. However, their small size and complex morphology compared to cerebral white matter structures makes mapping and segmentation challenging in neuroimaging. This results in a near absence of automated brainstem white matter tracing methods. We leverage diffusion MRI tractography to create BrainStem Bundle Tool (BSBT), which segments eight key white matter bundles in the rostral brainstem. BSBT performs automated segmentation on a custom probabilistic fiber map generated from tractography w"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2025.05.01.25326687"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12083584"],"repository":["biostudies-literature"],"pubmed_title":["Probabilistic Mapping and Automated Segmentation of Human Brainstem White Matter Bundles."],"pmcid":["PMC12083584"],"funding_grant_id":["U01 AG024904","U54 MH091657"],"pubmed_authors":["Sorby-Adams A","Shless J","Tregidgo H","Iglesias JE","Li J","Schreier DR","Maffei C","Healy BC","Destrieux C","Edlow BL","Brown EN","Freeman HJ","Olchanyi MD","Kinney HC"],"additional_accession":[]},"is_claimable":false,"name":"Probabilistic Mapping and Automated Segmentation of Human Brainstem White Matter Bundles.","description":"Brainstem white matter bundles are essential conduits for neural signaling involved in modulation of vital functions ranging from homeostasis to human consciousness. Their architecture forms the anatomic basis for brainstem connectomics, subcortical mesoscale circuit models, and deep brain navigation tools. However, their small size and complex morphology compared to cerebral white matter structures makes mapping and segmentation challenging in neuroimaging. This results in a near absence of automated brainstem white matter tracing methods. We leverage diffusion MRI tractography to create BrainStem Bundle Tool (BSBT), which segments eight key white matter bundles in the rostral brainstem. BSBT performs automated segmentation on a custom probabilistic fiber map generated from tractography w","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-04-08T18:25:50.602Z","creation":"2026-04-08T09:32:53.63Z"},"accession":"S-EPMC12083584","cross_references":{"pubmed":["40385397"],"doi":["10.1101/2025.05.01.25326687"]}}