biostudies-literatureUnknownTermorshuizen JDNIMH NIH HHSEating disorders -including anorexia nervosa (AN), bulimia nervosa, and binge eating disorder-are clinically distinct but exhibit symptom overlap and diagnostic crossover. Genomic analyses have mostly examined AN. We conducted the first genomic meta-analysis of binge eating behaviour (BE; 39,279 cases, 1,227,436 controls), alongside new analyses of AN (24,223 cases, 1,243,971 controls) and its subtypes (all European ancestries). We identified six loci associated with BE, including loci associated with higher body mass index (BMI) and impulse-control behaviours. AN GWAS yielded eight loci, validating six loci. Subsequent polygenic risk score analysis demonstrated an association with AN in two East Asian ancestry cohorts. BE and AN exhibited similar positive genetic correlations with psychiamedRxiv : the preprint server for health sciences2025.01.31.25321397https://www.ebi.ac.uk/biostudies/studies/S-EPMC12083633biostudies-literatureGenome-wide association studies of binge eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes.PMC12083633R01 MH124851Ayorech ZPalviainen TWoodside DBHavdahl AGorwood PKaprio JThornton LMMartin NGDanner UNFernandez-Aranda FZhang RRaevuori ASzatkiewicz JPMattingsdal MMeneguzzo PSealock JMCrawford SSeitz JSullivan PFRajcsanyi LSCorfield ECHellard SLHuckins LMMicali NDavies HLvan Furth EFSlachtova LLXu JGordon SDRamoz NHartman AMSavva ADmitrzak-Weglarz MDavis LKEstivill XFischer KAdan RADina CKrebs KHinney Ade Zwaan MDick DMWhiteman DCEgberts KMMonteleone AMNacmias BRipatti SLilenfeld LJulia ADeSocio JEMattheisen MColeman JRFavaro AYilmaz ZPedersen NLJohnson JSLanden MHebebrand JHerms SRoberts MELarsen JTJimenez-Murcia SLee SHKas MJHatzikotoulas KSigner RHDedoussis GGrove JTsitsika AEating Disorders Working Group of the Psychiatric Genomics Consortium, Estonian Biobank (EstBB)Schosser APetersen LVOlsen CMMitchell JEQi BKaye WHBaker JHSlopien ATermorshuizen JDTam FIImgart HLu YHudson JIAsk HMaj MMonteleone PCassina MRicca VEhrlich SPeters TKalsi GAndreassen OASingh KMedland SEMack TMCollantoni EKlump KLAbdulkadir MDuncan LEZipfel SBrandt HAParker RKiezebrink KMKeski-Rahkonen AHubel CHerpertz-Dahlmann BMitchell KSSchmidt UHLi DWagner GOphoff RABreen GGonidakis FPadyukov LYao SZvrskovec JSwiatkowska BKaminska DPerica VBKennedy MATenconi EMortensen PBPapezova HBergen AWSorbi SHakonarson HWade TDPinto DRybakowski FBirgegard AKaplan ASSantonastaso PAlfredsson LGuillaume Svan Elburg AAKarhunen LJKarwautz AFMaguire SLMunn-Chernoff MAPantel JJordan JRipke SForetova LScherer SWReichborn-Kjennerud TDennis JKForstner AJSlof-Op 't Landt MCWerge TJohnson CCrowley JJDegenhardt FKim YRGuintivano JDSchaumberg KEMiller ALNiarchou MKolb TStraub PSBuhren KCrow SBulik CMKennedy JLWatson HJGiegling ITortorella ARujescu DBurghardt RLehto KLissowska JTer Kuile ARfalseGenome-wide association studies of binge eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes.Eating disorders -including anorexia nervosa (AN), bulimia nervosa, and binge eating disorder-are clinically distinct but exhibit symptom overlap and diagnostic crossover. Genomic analyses have mostly examined AN. We conducted the first genomic meta-analysis of binge eating behaviour (BE; 39,279 cases, 1,227,436 controls), alongside new analyses of AN (24,223 cases, 1,243,971 controls) and its subtypes (all European ancestries). We identified six loci associated with BE, including loci associated with higher body mass index (BMI) and impulse-control behaviours. AN GWAS yielded eight loci, validating six loci. Subsequent polygenic risk score analysis demonstrated an association with AN in two East Asian ancestry cohorts. BE and AN exhibited similar positive genetic correlations with psychia2025-01-01T00:00:00Z2025 May2026-04-13T03:23:39.446Z2026-04-13T03:12:33.667ZS-EPMC120836334038538310.1101/2025.01.31.25321397