{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Zhou X"],"pubmed_abstract":["Coronary artery disease (CAD) remains a leading global cause of mortality. The expression of small ubiquitin-like modifier 1 (SUMO-1) is reduced in heart failure. However, the mechanisms underlying its modification in CAD remain underexplored. This study sought to identify SUMOylation-related biomarkers and elucidate the potential mechanisms in CAD pathogenesis. This study analyzed three CAD datasets (GSE42148, GSE23561, and GSE121893) alongside 187 SUMOylation-related genes (SRGs). The overlap between differentially expressed genes (DEGs) and SRGs was used to identify differentially expressed SUMOylation-related genes (DE-SRGs). Biomarkers were validated through expression profiling and receiver operating characteristic (ROC) curve analysis. Enrichment and immune infiltration analyses wer"],"journal":["Scientific reports"],"pagination":["17055"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12084532"],"repository":["biostudies-literature"],"pubmed_title":["The working mechanism of biomarkers related to sumoylation modification in coronary artery disease."],"pmcid":["PMC12084532"],"pubmed_authors":["Xiang B","Luo F","Li K","Zhou X"],"additional_accession":[]},"is_claimable":false,"name":"The working mechanism of biomarkers related to sumoylation modification in coronary artery disease.","description":"Coronary artery disease (CAD) remains a leading global cause of mortality. The expression of small ubiquitin-like modifier 1 (SUMO-1) is reduced in heart failure. However, the mechanisms underlying its modification in CAD remain underexplored. This study sought to identify SUMOylation-related biomarkers and elucidate the potential mechanisms in CAD pathogenesis. This study analyzed three CAD datasets (GSE42148, GSE23561, and GSE121893) alongside 187 SUMOylation-related genes (SRGs). The overlap between differentially expressed genes (DEGs) and SRGs was used to identify differentially expressed SUMOylation-related genes (DE-SRGs). Biomarkers were validated through expression profiling and receiver operating characteristic (ROC) curve analysis. Enrichment and immune infiltration analyses wer","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-02T20:54:09.305Z","creation":"2026-05-28T03:06:26.296Z"},"accession":"S-EPMC12084532","cross_references":{"pubmed":["40379803"],"doi":["10.1038/s41598-025-02099-4"]}}