{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(5)"],"submitter":["Wang LX"],"pubmed_abstract":["<h4>Background</h4>Insomnia is the most prevalent sleep disorder globally. Nuciferine (NF), a bioactive constituent extracted from Nelumbo nucifera leaves, is recognized for its diverse pharmacological activities. However, its sleep-regulating effects have not been investigated. This study aimed to delineate the therapeutic effects and underlying mechanisms of NF in mitigating insomnia.<h4>Methods</h4>The sedative-hypnotic effects of NF were assessed employing locomotor activity test, pentobarbital-induced sleep test, and electroencephalography-based sleep profiling. Insomnia symptoms in rodents were induced by serotonin (5-HT) depletion and environmental stress. The potential mechanisms of NF's action through the regulation of central serotonin system were also explored.<h4>Results</h4>Nu"],"journal":["The international journal of neuropsychopharmacology"],"pagination":["pyaf019"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12084828"],"repository":["biostudies-literature"],"pubmed_title":["Sedative and hypnotic effects of nuciferine: enhancing rodent sleep via serotonergic system modulation."],"pmcid":["PMC12084828"],"pubmed_authors":["Zhang YZ","Gu YF","Yang J","Li JC","Wang LX","Fan QY","Qiu RH","Li L","Wang J","Wang YK","Liu YM","Li S","Xue R","Zhang Y"],"additional_accession":[]},"is_claimable":false,"name":"Sedative and hypnotic effects of nuciferine: enhancing rodent sleep via serotonergic system modulation.","description":"<h4>Background</h4>Insomnia is the most prevalent sleep disorder globally. Nuciferine (NF), a bioactive constituent extracted from Nelumbo nucifera leaves, is recognized for its diverse pharmacological activities. However, its sleep-regulating effects have not been investigated. This study aimed to delineate the therapeutic effects and underlying mechanisms of NF in mitigating insomnia.<h4>Methods</h4>The sedative-hypnotic effects of NF were assessed employing locomotor activity test, pentobarbital-induced sleep test, and electroencephalography-based sleep profiling. Insomnia symptoms in rodents were induced by serotonin (5-HT) depletion and environmental stress. The potential mechanisms of NF's action through the regulation of central serotonin system were also explored.<h4>Results</h4>Nu","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-04-08T15:43:10.484Z","creation":"2026-04-08T05:20:24.427Z"},"accession":"S-EPMC12084828","cross_references":{"pubmed":["40160035"],"doi":["10.1093/ijnp/pyaf019"]}}