biostudies-literatureOstendorf APNINDS NIH HHS107831https://www.ebi.ac.uk/biostudies/studies/S-EPMC12087793biostudies-literatureUnknown151<h4>Background</h4>Acute seizures may evolve into status epilepticus (SE), prolonged and self-sustaining seizures that may result in brain injury or death. Rapid treatment with a benzodiazepine (BZD) is most effective. However, SE treatment remains delayed in many cases. We previously performed a single-center quality improvement study which resulted in more rapid treatment, decreased intensive care utilization, and decreased cost. Now, we are conducting a multicenter trial to test the hypothesis that pragmatic changes in treating acute inpatient seizures reduce time and are implementable across diverse hospital settings.<h4>Methods/design</h4>We designed a multicenter stepped wedge cluster randomized trial with three unidirectional 12-month steps following one baseline step. After dissemiContemporary clinical trialsTreating seizures faster: The Quality Improvement in Time to Treat Status Epilepticus (QuITT-SE) multicenter randomized stepped wedge clinical trial protocol.PMC12087793R01 NS133037Harrar DEisner MGaillard WDPress CMcHenry LFarias-Moeller RAbend NSVannatta KOstendorf APAppavu BBai SKroshus EGoodkin HPLoddenkemper TMorgan LAfalseTreating seizures faster: The Quality Improvement in Time to Treat Status Epilepticus (QuITT-SE) multicenter randomized stepped wedge clinical trial protocol.<h4>Background</h4>Acute seizures may evolve into status epilepticus (SE), prolonged and self-sustaining seizures that may result in brain injury or death. Rapid treatment with a benzodiazepine (BZD) is most effective. However, SE treatment remains delayed in many cases. We previously performed a single-center quality improvement study which resulted in more rapid treatment, decreased intensive care utilization, and decreased cost. Now, we are conducting a multicenter trial to test the hypothesis that pragmatic changes in treating acute inpatient seizures reduce time and are implementable across diverse hospital settings.<h4>Methods/design</h4>We designed a multicenter stepped wedge cluster randomized trial with three unidirectional 12-month steps following one baseline step. After dissemi2025-01-01T00:00:00Z2025 Apr2026-06-01T06:15:23.384Z2026-04-08T09:50:28.858ZS-EPMC120877933992926110.1016/j.cct.2025.107831