{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liang J"],"funding":["The national natural science foundation of china","Hubei province department of education"],"pagination":["e2500357122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12088403"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["122(19)"],"pubmed_abstract":["Regulating multistimulus responses in artificial systems remains a challenge in smart material development. We present a versatile chemical switching system that precisely controls the self-assembly of metal-organic cages via temperature and solvent changes. The key component, cyclo[2](1,3-(4,6-dimethyl)benzene) (4-pyridine)[6](1,3-(4,6-dimethyl)benzene) (<b>CP2</b>), was generated as three atropisomers (<b>1</b>, <b>2</b>, and <b>3</b>) with <i>C</i><sub>s</sub>, <i>C</i><sub>1</sub>, and <i>C</i><sub>2v</sub> symmetries. Thermally, metastable isomers (<b>1</b> and <b>2</b>) convert into the stable isomer (<b>3</b>), which reacts with Pd<sup>2+</sup> to form specific molecular cages. Depending on the solvent, either rectangular M<sub>2</sub>L<sub>2</sub> cages (<b>5'</b> and <b>5</b>) for"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Synergistic regulation of metal-organic cage architectures via temperature- and solvent-driven atropisomerism."],"pmcid":["PMC12088403"],"funding_grant_id":["92156009","Q20222506"],"pubmed_authors":["Yang YD","Bi QN","Guan AJ","Cui J","Li Q","Hao X","Wang H","Liang TL","Li X","Gong HY","Li ZA","Liang J","Peng LJ","Zhu KL","Chen XL"],"additional_accession":[]},"is_claimable":false,"name":"Synergistic regulation of metal-organic cage architectures via temperature- and solvent-driven atropisomerism.","description":"Regulating multistimulus responses in artificial systems remains a challenge in smart material development. We present a versatile chemical switching system that precisely controls the self-assembly of metal-organic cages via temperature and solvent changes. The key component, cyclo[2](1,3-(4,6-dimethyl)benzene) (4-pyridine)[6](1,3-(4,6-dimethyl)benzene) (<b>CP2</b>), was generated as three atropisomers (<b>1</b>, <b>2</b>, and <b>3</b>) with <i>C</i><sub>s</sub>, <i>C</i><sub>1</sub>, and <i>C</i><sub>2v</sub> symmetries. Thermally, metastable isomers (<b>1</b> and <b>2</b>) convert into the stable isomer (<b>3</b>), which reacts with Pd<sup>2+</sup> to form specific molecular cages. Depending on the solvent, either rectangular M<sub>2</sub>L<sub>2</sub> cages (<b>5'</b> and <b>5</b>) for","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-05T13:53:26.562Z","creation":"2026-05-17T03:12:32.461Z"},"accession":"S-EPMC12088403","cross_references":{"pubmed":["40339111"],"doi":["10.1073/pnas.2500357122"]}}