biostudies-literatureD'Amico AIntramural NIH HHSNIMH Intramural Research Programe33001https://www.ebi.ac.uk/biostudies/studies/S-EPMC12088826biostudies-literatureUnknown198(1)Cognitive deficits in people with bipolar disorder (BD) may be the result of the illness or its treatment, but they could also reflect genetic risk factors shared between BD and cognition. We investigated this question using empirical genetic relationships within a sample of patients with BD and their unaffected relatives. Participants with bipolar I, II, or schizoaffective disorder ("narrow" BD, n = 69), related mood disorders ("broad" BD, n = 135), and their clinically unaffected relatives (n = 227) completed five cognitive tests. General cognitive function (g) was quantified via principal components analysis (PCA). Heritability and genetic correlations were estimated with SOLAR-Eclipse. Participants with "narrow" or "broad" diagnoses showed deficits in g, although affect recognition wasAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric GeneticsIndependent inheritance of cognition and bipolar disorder in a family sample.PMC12088826ZIA MH002843Z01 MH0028421ZIAMH002843Akula ND'Amico ABesancon ESung HArbona-Lampaya AHosey KFreifeld AMcMahon FJLacbawan LGarcia JKnowles EEMDickinson DKassem LfalseIndependent inheritance of cognition and bipolar disorder in a family sample.Cognitive deficits in people with bipolar disorder (BD) may be the result of the illness or its treatment, but they could also reflect genetic risk factors shared between BD and cognition. We investigated this question using empirical genetic relationships within a sample of patients with BD and their unaffected relatives. Participants with bipolar I, II, or schizoaffective disorder ("narrow" BD, n = 69), related mood disorders ("broad" BD, n = 135), and their clinically unaffected relatives (n = 227) completed five cognitive tests. General cognitive function (g) was quantified via principal components analysis (PCA). Heritability and genetic correlations were estimated with SOLAR-Eclipse. Participants with "narrow" or "broad" diagnoses showed deficits in g, although affect recognition was2025-01-01T00:00:00Z2025 Jan2026-06-06T08:37:30.941Z2026-05-27T03:12:40.735ZS-EPMC120888263901187210.1002/ajmg.b.33001