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Evidence about the cost-effectiveness of intravenous (IV) sedation with these medications is lacking.<h4>Objective</h4>To investigate the cost-effectiveness of dexmedetomidine-, clonidine-, and propofol-based IV sedation in patients with critical illness receiving mechanical ventilation.<h4>Design, setting, and participants</h4>This economic evaluation used within-trial cost-utility analysis with a 6-month time horizon comparing dexmedetomidine-, clonidine-, and propofol-based IV sedation from a UK National Health Service and Personal Social Services perspective, with individual-level data collected from the Alpha 2 Agonists"],"journal":["JAMA network open"],"pagination":["e2517533"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12090026"],"repository":["biostudies-literature"],"pubmed_title":["Cost-Effectiveness of α2 Agonists for Intravenous Sedation in Patients With Critical Illness."],"pmcid":["PMC12090026"],"pubmed_authors":["Singleton J","Weir CJ","Humphrey 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Evidence about the cost-effectiveness of intravenous (IV) sedation with these medications is lacking.<h4>Objective</h4>To investigate the cost-effectiveness of dexmedetomidine-, clonidine-, and propofol-based IV sedation in patients with critical illness receiving mechanical ventilation.<h4>Design, setting, and participants</h4>This economic evaluation used within-trial cost-utility analysis with a 6-month time horizon comparing dexmedetomidine-, clonidine-, and propofol-based IV sedation from a UK National Health Service and Personal Social Services perspective, with individual-level data collected from the Alpha 2 Agonists","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-05T16:13:40.532Z","creation":"2026-05-18T03:12:42.879Z"},"accession":"S-EPMC12090026","cross_references":{"pubmed":["40388914"],"doi":["10.1001/jamanetworkopen.2025.17533"]}}