{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(4)"],"submitter":["Zhan Y"],"pubmed_abstract":["<h4>Background</h4>Seasonal influenza poses a high risk of death worldwide. Lianhua Qingwen (LHQW) is effective in shortening the time to symptom alleviation in patients with influenza, but there is a lack of convincing clinical trials targeting influenza prevention. This study aims to evaluate both efficacy and safety of LHQW in the preventing spread of seasonal influenza among close contacts under a cluster setting.<h4>Methods</h4>This study is a randomized, double-blind, multicenter clinical trial to evaluate the preventive efficacy and safety of LHQW in close contacts in a residential environments; 1,884 close contacts will be enrolled in this trial at 72 centers in China, with a five-day duration of LHQW or placebo. All participants were randomized into the LHQW and placebo groups in "],"journal":["Journal of thoracic disease"],"pagination":["2623-2633"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12090131"],"repository":["biostudies-literature"],"pubmed_title":["Preventive effect of Lianhua Qingwen capsule on close contacts of seasonal influenza in residential environments: protocol for a multicenter, randomized, double-blind, placebo-controlled study."],"pmcid":["PMC12090131"],"pubmed_authors":["Liang S","Hu Y","Li Q","Yang C","Zhan Y","Hou L","Zhong N","Liu Y","Li Y","Yang Z","Fang Z","Luo J","Zhao K"],"additional_accession":[]},"is_claimable":false,"name":"Preventive effect of Lianhua Qingwen capsule on close contacts of seasonal influenza in residential environments: protocol for a multicenter, randomized, double-blind, placebo-controlled study.","description":"<h4>Background</h4>Seasonal influenza poses a high risk of death worldwide. Lianhua Qingwen (LHQW) is effective in shortening the time to symptom alleviation in patients with influenza, but there is a lack of convincing clinical trials targeting influenza prevention. This study aims to evaluate both efficacy and safety of LHQW in the preventing spread of seasonal influenza among close contacts under a cluster setting.<h4>Methods</h4>This study is a randomized, double-blind, multicenter clinical trial to evaluate the preventive efficacy and safety of LHQW in close contacts in a residential environments; 1,884 close contacts will be enrolled in this trial at 72 centers in China, with a five-day duration of LHQW or placebo. All participants were randomized into the LHQW and placebo groups in ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-06T16:49:23.388Z","creation":"2026-06-02T03:12:24.628Z"},"accession":"S-EPMC12090131","cross_references":{"pubmed":["40400963"],"doi":["10.21037/jtd-24-1542"]}}