biostudies-literatureUnknown17(4)Zhan Y<h4>Background</h4>Seasonal influenza poses a high risk of death worldwide. Lianhua Qingwen (LHQW) is effective in shortening the time to symptom alleviation in patients with influenza, but there is a lack of convincing clinical trials targeting influenza prevention. This study aims to evaluate both efficacy and safety of LHQW in the preventing spread of seasonal influenza among close contacts under a cluster setting.<h4>Methods</h4>This study is a randomized, double-blind, multicenter clinical trial to evaluate the preventive efficacy and safety of LHQW in close contacts in a residential environments; 1,884 close contacts will be enrolled in this trial at 72 centers in China, with a five-day duration of LHQW or placebo. All participants were randomized into the LHQW and placebo groups in Journal of thoracic disease2623-2633https://www.ebi.ac.uk/biostudies/studies/S-EPMC12090131biostudies-literaturePreventive effect of Lianhua Qingwen capsule on close contacts of seasonal influenza in residential environments: protocol for a multicenter, randomized, double-blind, placebo-controlled study.PMC12090131Liang SHu YLi QYang CZhan YHou LZhong NLiu YLi YYang ZFang ZLuo JZhao KfalsePreventive effect of Lianhua Qingwen capsule on close contacts of seasonal influenza in residential environments: protocol for a multicenter, randomized, double-blind, placebo-controlled study.<h4>Background</h4>Seasonal influenza poses a high risk of death worldwide. Lianhua Qingwen (LHQW) is effective in shortening the time to symptom alleviation in patients with influenza, but there is a lack of convincing clinical trials targeting influenza prevention. This study aims to evaluate both efficacy and safety of LHQW in the preventing spread of seasonal influenza among close contacts under a cluster setting.<h4>Methods</h4>This study is a randomized, double-blind, multicenter clinical trial to evaluate the preventive efficacy and safety of LHQW in close contacts in a residential environments; 1,884 close contacts will be enrolled in this trial at 72 centers in China, with a five-day duration of LHQW or placebo. All participants were randomized into the LHQW and placebo groups in 2025-01-01T00:00:00Z2025 Apr2026-06-06T16:49:23.388Z2026-06-02T03:12:24.628ZS-EPMC120901314040096310.21037/jtd-24-1542