{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Hou M"],"pubmed_abstract":["Newborn piglet diarrhea caused by enterotoxigenic <i>Escherichia coli</i> (ETEC) causes serious economic losses in the swine industry worldwide. Heat-stable enterotoxins (STa) secreted by ETEC can damage the intestine, resulting in villus atrophy and shedding, which is the main cause of diarrhea in newborn piglets; however, the mechanism is not clear. This experiment was conducted <i>in vivo</i> (three-day-old suckling mice) and <i>in vitro</i> (IPEC-J2 cells) to explore the effect of STa on the intestinal epithelium by comparing the differences after infection with STa toxin-secreting <i>E. coli</i> O142 or STa-knockout <i>E. coli</i> O142ΔestA. The results showed that STa caused diarrhea, small intestinal edema, atrophy and rupture of small intestinal villi, and death in a dose-dependent"],"journal":["Frontiers in veterinary science"],"pagination":["1545696"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12090930"],"repository":["biostudies-literature"],"pubmed_title":["Heat-stable enterotoxin induced apoptosis in small intestine epithelial cells via mitochondrial oxidative phosphorylation pathway."],"pmcid":["PMC12090930"],"pubmed_authors":["Hou M","Yang W","Liu J","Shi B","Dong X","Liu N","Sun S","Feng Q"],"additional_accession":[]},"is_claimable":false,"name":"Heat-stable enterotoxin induced apoptosis in small intestine epithelial cells via mitochondrial oxidative phosphorylation pathway.","description":"Newborn piglet diarrhea caused by enterotoxigenic <i>Escherichia coli</i> (ETEC) causes serious economic losses in the swine industry worldwide. Heat-stable enterotoxins (STa) secreted by ETEC can damage the intestine, resulting in villus atrophy and shedding, which is the main cause of diarrhea in newborn piglets; however, the mechanism is not clear. This experiment was conducted <i>in vivo</i> (three-day-old suckling mice) and <i>in vitro</i> (IPEC-J2 cells) to explore the effect of STa on the intestinal epithelium by comparing the differences after infection with STa toxin-secreting <i>E. coli</i> O142 or STa-knockout <i>E. coli</i> O142ΔestA. The results showed that STa caused diarrhea, small intestinal edema, atrophy and rupture of small intestinal villi, and death in a dose-dependent","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-04-08T18:38:28.953Z","creation":"2026-04-08T09:50:34.993Z"},"accession":"S-EPMC12090930","cross_references":{"pubmed":["40395804"],"doi":["10.3389/fvets.2025.1545696"]}}