biostudies-literatureMenon AVNCATS NIH HHSIndiana Clinical and Translational Sciences InstituteNational Institutes of HealthPurdue College of EngineeringPurdue Davidson School of Chemical EngineeringNIH HHSOffice of Naval ResearchNational Science FoundationPurdue James Tarpo Jr. and Margaret Tarpo Department of Chemistry2243-2256https://www.ebi.ac.uk/biostudies/studies/S-EPMC12091576biostudies-literatureUnknown112(12)Wound closure in surgeries is traditionally achieved using invasive methods such as sutures and staples. Adhesion-based wound closure methods such as tissue adhesives, sealants, and hemostats are slowly replacing these methods due to their ease of application. Although several chemistries have been developed and used commercially for wound closure, there is still a need for better tissue adhesives from the point of view of toxicity, wet-adhesion strength, and long-term bonding. Catechol chemistry has shown great promise in developing wet-set adhesives that meet these criteria. Herein, we have studied the biocompatibility of a catechol-based copolymer adhesive, poly([dopamine methacrylamide]-co-[methyl methacrylate]-co-[poly(ethylene glycol) methyl ether methacrylate]) or poly(catechol-MMA-Journal of biomedical materials research. Part ABiocompatibility of mussel-inspired water-soluble tissue adhesives.PMC12091576N000‐14‐19‐1‐2342DMR-2104783DMR‐2104783N000‐14‐22‐1‐2408UL1TR001108N000-14-22-1-2408UM1 TR004402UL1 TR001108N000-14-19-1-2342Brown CEMenon AVBreur GJNarayanan SKCrain CJPutnam-Neeb AAWilker JJLiu JCfalseBiocompatibility of mussel-inspired water-soluble tissue adhesives.Wound closure in surgeries is traditionally achieved using invasive methods such as sutures and staples. Adhesion-based wound closure methods such as tissue adhesives, sealants, and hemostats are slowly replacing these methods due to their ease of application. Although several chemistries have been developed and used commercially for wound closure, there is still a need for better tissue adhesives from the point of view of toxicity, wet-adhesion strength, and long-term bonding. Catechol chemistry has shown great promise in developing wet-set adhesives that meet these criteria. Herein, we have studied the biocompatibility of a catechol-based copolymer adhesive, poly([dopamine methacrylamide]-co-[methyl methacrylate]-co-[poly(ethylene glycol) methyl ether methacrylate]) or poly(catechol-MMA-2024-01-01T00:00:00Z2024 Dec2026-06-05T20:59:44.166Z2026-05-21T03:12:56.344ZS-EPMC120915763898820010.1002/jbm.a.37775