{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ossenkoppele R"],"funding":["European Research Council","NIA NIH HHS","ZonMw"],"pagination":["883-896"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12092243"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(5)"],"pubmed_abstract":["Plasma p-tau217 and tau positron emission tomography (PET) are strong prognostic biomarkers in Alzheimer's disease (AD), but their relative performance in predicting future cognitive decline among cognitively unimpaired (CU) individuals is unclear. In a head-to-head comparison study including nine cohorts and 1,474 individuals, we show that plasma p-tau217 and medial temporal lobe tau-PET signal display similar associations with cognitive decline on a global cognitive composite test (R<sup>2</sup><sub>PET</sub> = 0.34 versus R<sup>2</sup><sub>plasma</sub> = 0.33, P<sub>difference</sub> = 0.653) and with progression to mild cognitive impairment (hazard ratio (HR)<sub>PET</sub> = 1.61 (1.48-1.76) versus HR<sub>plasma</sub> = 1.57 (1.43-1.72), P<sub>difference</sub> = 0.322). Combined plasma "],"journal":["Nature aging"],"pubmed_title":["Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials."],"pmcid":["PMC12092243"],"funding_grant_id":["R01 AG027161","U01 AG006786","10510032120003","R56 AG061900","73305095007","101096455","R01 AG070941","P30 AG066444","R01 AG021155","P01 AG026276","R01 AG083740","RF1 AG061900","P01 AG003991"],"pubmed_authors":["van der Flier WM","Karlsson L","Jack CR","van de Giessen E","Bateman RJ","Dore V","Rowe C","Schindler SE","Johnson SC","Villeneuve S","Feizpour A","Coomans EM","Therriault J","Salvado G","Rahmouni N","Janelidze S","Palmqvist S","Rosa-Neto P","Hansson O","Bali D","Masters CL","Pichet Binette A","Ossenkoppele R","Stomrud E","Petersen RC","PREVENT-AD Research Group","Doecke JD","Jonaitis EM","Wiste HJ","Mattsson-Carlgren N","Benzinger TLS","Teunissen CE"],"additional_accession":[]},"is_claimable":false,"name":"Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials.","description":"Plasma p-tau217 and tau positron emission tomography (PET) are strong prognostic biomarkers in Alzheimer's disease (AD), but their relative performance in predicting future cognitive decline among cognitively unimpaired (CU) individuals is unclear. In a head-to-head comparison study including nine cohorts and 1,474 individuals, we show that plasma p-tau217 and medial temporal lobe tau-PET signal display similar associations with cognitive decline on a global cognitive composite test (R<sup>2</sup><sub>PET</sub> = 0.34 versus R<sup>2</sup><sub>plasma</sub> = 0.33, P<sub>difference</sub> = 0.653) and with progression to mild cognitive impairment (hazard ratio (HR)<sub>PET</sub> = 1.61 (1.48-1.76) versus HR<sub>plasma</sub> = 1.57 (1.43-1.72), P<sub>difference</sub> = 0.322). Combined plasma ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-01T10:23:41.35Z","creation":"2026-04-08T11:24:46.12Z"},"accession":"S-EPMC12092243","cross_references":{"pubmed":["40155777"],"doi":["10.1038/s43587-025-00835-z"]}}