{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gan S"],"funding":["NIDDK NIH HHS","NCI NIH HHS","Memorial Sloan Kettering Cancer Center"],"pagination":["1693-1712.e24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12093277"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(10)"],"pubmed_abstract":["Brain metastasis, a serious complication of cancer, hinges on the initial survival, microenvironment adaptation, and outgrowth of disseminated cancer cells. To understand the early stages of brain colonization, we investigated two prevalent sources of cerebral relapse, triple-negative (TNBC) and HER2+ (HER2BC) breast cancers. Using mouse models and human tissue samples, we found that these tumor types colonize the brain, with a preference for distinctive tumor architectures, stromal interfaces, and autocrine programs. TNBC models tend to form perivascular sheaths with diffusive contact with astrocytes and microglia. In contrast, HER2BC models tend to form compact spheroids driven by autonomous tenascin C production, segregating stromal cells to the periphery. Single-cell transcriptomics of"],"journal":["Cancer cell"],"pubmed_title":["Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain."],"pmcid":["PMC12093277"],"funding_grant_id":["P30 CA008748","R01 DK127821","U54 CA209975","P01 CA129243","U54 CA274492"],"pubmed_authors":["Macalinao DG","Tian L","Pe'er D","Jin X","Murali R","Chanda P","Hadjantonakis AK","Bibby C","Moss NS","Gan S","Chatila W","Basnet H","Bale TA","Massague J","Brogi E","Seffar E","Schultz N","Atri P","Muller JT","Karacay A","Shahoei SH"],"additional_accession":[]},"is_claimable":false,"name":"Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain.","description":"Brain metastasis, a serious complication of cancer, hinges on the initial survival, microenvironment adaptation, and outgrowth of disseminated cancer cells. To understand the early stages of brain colonization, we investigated two prevalent sources of cerebral relapse, triple-negative (TNBC) and HER2+ (HER2BC) breast cancers. Using mouse models and human tissue samples, we found that these tumor types colonize the brain, with a preference for distinctive tumor architectures, stromal interfaces, and autocrine programs. TNBC models tend to form perivascular sheaths with diffusive contact with astrocytes and microglia. In contrast, HER2BC models tend to form compact spheroids driven by autonomous tenascin C production, segregating stromal cells to the periphery. Single-cell transcriptomics of","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-04T11:02:52.231Z","creation":"2026-05-08T03:11:03.78Z"},"accession":"S-EPMC12093277","cross_references":{"pubmed":["39270646"],"doi":["10.1016/j.ccell.2024.08.015"]}}