{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(1)"],"submitter":["Kotake K"],"pubmed_abstract":["<h4>Background</h4>Topiramate has shown efficacy in reducing alcohol consumption and is increasingly used off-label for individuals with harmful alcohol use. However, findings regarding the moderating effect of the GRIK1 rs2832407 single nucleotide polymorphism (SNP) on treatment outcomes remain inconsistent, highlighting the need for a review of the current evidence. We evaluated whether the GRIK1 rs2832407 SNP moderates the efficacy and safety of topiramate treatment for alcohol use.<h4>Methods</h4>We searched multiple databases including MEDLINE, Cochrane Library, ClinicalTrials.gov, and the International Clinical Trials Registry Platform up to December 1, 2024. Randomized controlled trials (RCTs) comparing treatment outcomes of topiramate in patients with alcohol use who were homozygou"],"journal":["Journal of pharmaceutical health care and sciences"],"pagination":["42"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12093777"],"repository":["biostudies-literature"],"pubmed_title":["GRIK1 genotype and effect of topiramate for alcohol use: a systematic review."],"pmcid":["PMC12093777"],"pubmed_authors":["Kotake K","Matsunuma S"],"additional_accession":[]},"is_claimable":false,"name":"GRIK1 genotype and effect of topiramate for alcohol use: a systematic review.","description":"<h4>Background</h4>Topiramate has shown efficacy in reducing alcohol consumption and is increasingly used off-label for individuals with harmful alcohol use. However, findings regarding the moderating effect of the GRIK1 rs2832407 single nucleotide polymorphism (SNP) on treatment outcomes remain inconsistent, highlighting the need for a review of the current evidence. We evaluated whether the GRIK1 rs2832407 SNP moderates the efficacy and safety of topiramate treatment for alcohol use.<h4>Methods</h4>We searched multiple databases including MEDLINE, Cochrane Library, ClinicalTrials.gov, and the International Clinical Trials Registry Platform up to December 1, 2024. Randomized controlled trials (RCTs) comparing treatment outcomes of topiramate in patients with alcohol use who were homozygou","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-01T05:21:35.94Z","creation":"2026-04-08T09:33:01.634Z"},"accession":"S-EPMC12093777","cross_references":{"pubmed":["40394707"],"doi":["10.1186/s40780-025-00449-y"]}}