{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brown AP"],"funding":["National Institute of Health United states","NIAID NIH HHS","NIEHS NIH HHS","NIAMS NIH HHS","NIH HHS"],"pagination":["dvaf007"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12094077"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Previous studies have demonstrated that ten-eleven translocation methylcytosine dioxygenase 1 (TET1) plays a protective role against house dust mite (HDM)-induced allergic airway inflammation. TET1 transcriptionally responded to HDM extract and regulated the expression of genes involved in asthma in human bronchial epithelial cells (HBECs). How TET1 regulates the expression of these genes, however, is unknown. To this end, we measured mRNA expression, DNA methylation, chromatin accessibility, and histone modifications in control and <i>TET1</i> knockdown HBECs treated or untreated with HDM extract. Throughout our analyses of multiomics data, we detected significant similarities between the effects of <i>TET1</i> knockdown alone and the effects of HDM treatment alone, all enriched for asthm"],"journal":["Environmental epigenetics"],"pubmed_title":["Silencing &lt;i&gt;TET1&lt;/i&gt; expression alters the epigenomic landscape and amplifies transcriptomic responses to allergen in airway epithelial cells."],"pmcid":["PMC12094077"],"funding_grant_id":["R01 AI141569","P30 ES023513","P30 AR070549","U01 AI150748","P51 OD011107","R01AI141569, U01AI150748, P30AR070549, P30ES023513"],"pubmed_authors":["Brown AP","Ji H","Barski A","Weirauch MT","Cai L","Elston S","Pham C","Parameswaran S"],"additional_accession":[]},"is_claimable":false,"name":"Silencing &lt;i&gt;TET1&lt;/i&gt; expression alters the epigenomic landscape and amplifies transcriptomic responses to allergen in airway epithelial cells.","description":"Previous studies have demonstrated that ten-eleven translocation methylcytosine dioxygenase 1 (TET1) plays a protective role against house dust mite (HDM)-induced allergic airway inflammation. TET1 transcriptionally responded to HDM extract and regulated the expression of genes involved in asthma in human bronchial epithelial cells (HBECs). How TET1 regulates the expression of these genes, however, is unknown. To this end, we measured mRNA expression, DNA methylation, chromatin accessibility, and histone modifications in control and <i>TET1</i> knockdown HBECs treated or untreated with HDM extract. Throughout our analyses of multiomics data, we detected significant similarities between the effects of <i>TET1</i> knockdown alone and the effects of HDM treatment alone, all enriched for asthm","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-04-08T18:59:27.032Z","creation":"2026-04-08T11:24:03.069Z"},"accession":"S-EPMC12094077","cross_references":{"pubmed":["40401166"],"doi":["10.1093/eep/dvaf007"]}}