{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Feng Y"],"funding":["Hubei Chutian Program","Department of Science and Technology of Hubei Province"],"pagination":["208"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12095718"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["82(1)"],"pubmed_abstract":["Chromatin remodeling factors are involved in the inflammatory responses, contributing to tissue damage and multi-organ dysfunction in COVID-19 patients. However, the underlying mechanisms remain unclear. In this study, high-dimensional analyses of single-cell RNA sequencing and single-cell ATAC sequencing data revealed increased chromatin accessibility at the promoters or enhancers of the pro-inflammatory cytokine tissue inhibitor of metalloproteinase-1 (TIMP1), as well as altered gene transcription profiles in monocytes from COVID-19 patients. Motif enrichment and positive regulators analyses identified SMARCC1, the core subunit of the chromatin remodeling complex, and the transcription factor JUND as positive regulators to co-modulate TIMP1 expression. In-vitro experiments, co-immunoprec"],"journal":["Cellular and molecular life sciences : CMLS"],"pubmed_title":["Inflammatory metabolite 7α,25-OHC promotes TIMP1 expression in COVID-19 monocytes through synergy effect of SMARCC1/JUND/H3K27ac."],"pmcid":["PMC12095718"],"funding_grant_id":["1180011","2022EHB035"],"pubmed_authors":["Yang H","Wu Z","Yuan S","Li J","Feng Y","Hu K","Wang Y","Luo ZH","Wang Z","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Inflammatory metabolite 7α,25-OHC promotes TIMP1 expression in COVID-19 monocytes through synergy effect of SMARCC1/JUND/H3K27ac.","description":"Chromatin remodeling factors are involved in the inflammatory responses, contributing to tissue damage and multi-organ dysfunction in COVID-19 patients. However, the underlying mechanisms remain unclear. In this study, high-dimensional analyses of single-cell RNA sequencing and single-cell ATAC sequencing data revealed increased chromatin accessibility at the promoters or enhancers of the pro-inflammatory cytokine tissue inhibitor of metalloproteinase-1 (TIMP1), as well as altered gene transcription profiles in monocytes from COVID-19 patients. Motif enrichment and positive regulators analyses identified SMARCC1, the core subunit of the chromatin remodeling complex, and the transcription factor JUND as positive regulators to co-modulate TIMP1 expression. In-vitro experiments, co-immunoprec","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-06-01T22:21:38.977Z","creation":"2026-05-22T03:08:00.352Z"},"accession":"S-EPMC12095718","cross_references":{"pubmed":["40399563"],"doi":["10.1007/s00018-025-05721-w"]}}