{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(3)"],"submitter":["Ranganathan UD"],"funding":["CDC"],"pubmed_abstract":["<h4>Objectives</h4>To evaluate the effect of high-dose isoniazid in patients with isoniazid-resistant TB by its bactericidal activity after 1 or more weeks of treatment.<h4>Subjects and methods</h4>Using the rapid direct method of phenotypic drug susceptibility testing, we screened persons with positive sputum microscopy results and genotypic drug resistance for isoniazid resistance. Those with no growth at a critical concentration of 2.0 mg/L were invited to participate in a trial of high-dose isoniazid monotherapy lasting 6 days. After 3 days of no treatment, patients received isoniazid 15 mg/kg and were followed with serial quantitative sputum cultures from Days 0 to 6.<h4>Results</h4>We enrolled 15 patients after a median of 2 weeks standard first-line treatment. Their median bacillary"],"journal":["JAC-antimicrobial resistance"],"pagination":["dlaf072"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12096161"],"repository":["biostudies-literature"],"pubmed_title":["High-dose isoniazid for TB with low-to-moderate isoniazid resistance after 1 week of treatment."],"pmcid":["PMC12096161"],"pubmed_authors":["Sridhar R","Nair D","Swaminathan S","Eisenach KD","Ranganathan UD","Devaleenal Daniel B","Radhika G","Maheswaran K","Lavanya J","Devika K","Kumar S","RaviKumar D","Mangalambal G","Balaji S","Srinivasan R","Baskaran M","Sangamithirai D","Tripathy S","Smith-Jeffcoat SE","Cegielski JP"],"additional_accession":[]},"is_claimable":false,"name":"High-dose isoniazid for TB with low-to-moderate isoniazid resistance after 1 week of treatment.","description":"<h4>Objectives</h4>To evaluate the effect of high-dose isoniazid in patients with isoniazid-resistant TB by its bactericidal activity after 1 or more weeks of treatment.<h4>Subjects and methods</h4>Using the rapid direct method of phenotypic drug susceptibility testing, we screened persons with positive sputum microscopy results and genotypic drug resistance for isoniazid resistance. Those with no growth at a critical concentration of 2.0 mg/L were invited to participate in a trial of high-dose isoniazid monotherapy lasting 6 days. After 3 days of no treatment, patients received isoniazid 15 mg/kg and were followed with serial quantitative sputum cultures from Days 0 to 6.<h4>Results</h4>We enrolled 15 patients after a median of 2 weeks standard first-line treatment. Their median bacillary","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-03T02:43:07.225Z","creation":"2026-04-23T03:11:41.47Z"},"accession":"S-EPMC12096161","cross_references":{"pubmed":["40406736"],"doi":["10.1093/jacamr/dlaf072"]}}