biostudies-literatureUnknown160(7)Ni T<h4>Importance</h4>Postinduction hemodynamic instability is a frequent complication among patients with severe aortic stenosis (AS). Using cipepofol as the anesthesia agent may reduce the incidence and severity of hemodynamic instability.<h4>Objective</h4>To assess whether cipepofol outperforms propofol in maintaining postinduction hemodynamic stability in patients with AS.<h4>Design, setting, and participants</h4>This single-center, randomized clinical trial was conducted from June 29, 2023, to July 8, 2024, at the Second Affiliated Hospital of Zhejiang University School of Medicine in China. Patients with AS scheduled for transcatheter aortic valve replacement (TAVR) were eligible for inclusion.<h4>Interventions</h4>Participants were randomized 1:1 to receive either cipepofol or propofolJAMA surgery763-770https://www.ebi.ac.uk/biostudies/studies/S-EPMC12096327biostudies-literatureHemodynamic Impact of Cipepofol vs Propofol During Anesthesia Induction in Patients With Severe Aortic Stenosis: A Randomized Clinical Trial.PMC12096327Yan MZou JYi YHu YLuo GNi TZhou XGao QZhao LYao YXiao JTao XWang TWu SLv TChen YXie CXu ZZhou JfalseHemodynamic Impact of Cipepofol vs Propofol During Anesthesia Induction in Patients With Severe Aortic Stenosis: A Randomized Clinical Trial.<h4>Importance</h4>Postinduction hemodynamic instability is a frequent complication among patients with severe aortic stenosis (AS). Using cipepofol as the anesthesia agent may reduce the incidence and severity of hemodynamic instability.<h4>Objective</h4>To assess whether cipepofol outperforms propofol in maintaining postinduction hemodynamic stability in patients with AS.<h4>Design, setting, and participants</h4>This single-center, randomized clinical trial was conducted from June 29, 2023, to July 8, 2024, at the Second Affiliated Hospital of Zhejiang University School of Medicine in China. Patients with AS scheduled for transcatheter aortic valve replacement (TAVR) were eligible for inclusion.<h4>Interventions</h4>Participants were randomized 1:1 to receive either cipepofol or propofol2025-01-01T00:00:00Z2025 Jul2026-06-03T02:44:23.958Z2026-04-23T03:10:50.974ZS-EPMC120963274039742710.1001/jamasurg.2025.1299