{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Motsoeneng BM"],"funding":["Poliomyelitis Research Foundation","Department of Science and Technology","Collaborative Influenza Vaccine Innovation","NIAID NIH HHS","Centre for the AIDS Program of Research","Department of Science and Innovation","University of the Witwatersrand","NIH","Centers of Excellence for Influenza Research and Response","South African National Research Foundation","Department of Science and Innovation, South Africa","South Africa","National Research Foundation","National Research Foundation, South Africa"],"pagination":["1329-1336"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12102481"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["230(6)"],"pubmed_abstract":["<h4>Background</h4>Future vaccine candidates aim to elicit antibodies against the conserved hemagglutinin stalk domain. Understanding the protective mechanism of these antibodies, which mediate broad neutralization and Fc-mediated functions, following seasonal vaccination is critical.<h4>Methods</h4>Plasma samples were obtained from pregnant women with or without HIV-1 enrolled in a randomised trial (138 trivalent inactivated vaccine [TIV] and 145 placebo recipients). Twenty-three influenza cases were confirmed within 6 months postpartum. We measured H1 stalk-specific antibody-dependent cellular phagocytosis (ADCP), complement deposition (ADCD) and cellular cytotoxicity (ADCC) at enrolment and 1-month postvaccination.<h4>Results</h4>Lower H1 stalk-specific ADCP and ADCD activity was detect"],"journal":["The Journal of infectious diseases"],"pubmed_title":["Hemagglutinin Stalk-Specific Fc-Mediated Functions Are Associated With Protection Against Influenza Illness After Seasonal Influenza Vaccination."],"pmcid":["PMC12102481"],"funding_grant_id":["75N93021C00014","75N93019C00051","20/36","98341"],"pubmed_authors":["Richardson SI","Motsoeneng BM","Moore PL","Dhar N","Krammer F","Madhi SA","Nunes MC"],"additional_accession":[]},"is_claimable":false,"name":"Hemagglutinin Stalk-Specific Fc-Mediated Functions Are Associated With Protection Against Influenza Illness After Seasonal Influenza Vaccination.","description":"<h4>Background</h4>Future vaccine candidates aim to elicit antibodies against the conserved hemagglutinin stalk domain. Understanding the protective mechanism of these antibodies, which mediate broad neutralization and Fc-mediated functions, following seasonal vaccination is critical.<h4>Methods</h4>Plasma samples were obtained from pregnant women with or without HIV-1 enrolled in a randomised trial (138 trivalent inactivated vaccine [TIV] and 145 placebo recipients). Twenty-three influenza cases were confirmed within 6 months postpartum. We measured H1 stalk-specific antibody-dependent cellular phagocytosis (ADCP), complement deposition (ADCD) and cellular cytotoxicity (ADCC) at enrolment and 1-month postvaccination.<h4>Results</h4>Lower H1 stalk-specific ADCP and ADCD activity was detect","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-05-29T14:23:54.971Z","creation":"2026-04-08T04:59:51.698Z"},"accession":"S-EPMC12102481","cross_references":{"pubmed":["38743692"],"doi":["10.1093/infdis/jiae241"]}}